Unidirectional cell crawling model guided by extracellular cues

Journal of Biomechanical Engineering
Zhanjiang Wang, Yuxu Geng

Abstract

Cell migration is a highly regulated and complex cellular process to maintain proper homeostasis for various biological processes. Extracellular environment was identified as the main affecting factors determining the direction of cell crawling. It was observed experimentally that the cell prefers migrating to the area with denser or stiffer array of microposts. In this article, an integrated unidirectional cell crawling model was developed to investigate the spatiotemporal dynamics of unidirectional cell migration, which incorporates the dominating intracellular biochemical processes, biomechanical processes and the properties of extracellular micropost arrays. The interpost spacing and the stiffness of microposts are taken into account, respectively, to study the mechanism of unidirectional cell locomotion and the guidance of extracellular influence cues on the direction of unidirectional cell crawling. The model can explain adequately the unidirectional crawling phenomena observed in experiments such as "spatiotaxis" and "durotaxis," which allows us to obtain further insights into cell migration.

References

Jan 21, 1967·Nature·S B Carter
Jul 1, 1981·The Journal of Cell Biology·W T Chen
Apr 29, 1994·Science·R SinghviD E Ingber
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
May 21, 1993·Science·T P Stossel
Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·C G Galbraith, M P Sheetz
Sep 18, 1998·Biochimica Et Biophysica Acta·J V SmallK I Anderson
Mar 30, 1999·Biophysical Journal·M Dembo, Y L Wang
Nov 17, 1999·Molecular Biology of the Cell·K BurtonD L Taylor
Dec 28, 1999·Science·A R Horwitz, J T Parsons
Jan 7, 2000·Annals of Biomedical Engineering·P RoyJ V Jester
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Feb 8, 2002·American Journal of Physiology. Cell Physiology·James P ButlerJeffrey J Fredberg
Jul 12, 2002·Cell Motility and the Cytoskeleton·Ning WangDonald E Ingber
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John L TanChristopher S Chen
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·I B Bischofs, U S Schwarz
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander D BershadskyBenjamin Geiger
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Dec 13, 2003·Bulletin of Mathematical Biology·Maria E Gracheva, Hans G Othmer
Jul 17, 2004·Annual Review of Biomedical Engineering·Christopher S ChenJoe Tien
Aug 24, 2004·Biomechanics and Modeling in Mechanobiology·S NaJ D Humphrey
Oct 27, 2004·Experimental Cell Research·David Chodniewicz, Richard L Klemke
Dec 2, 2004·Cell Motility and the Cytoskeleton·Tony YeungPaul A Janmey
Jan 26, 2005·Journal of Cellular Physiology·Shelly R Peyton, Andrew J Putnam
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olivia du RoureBenoit Ladoux
May 3, 2005·Journal of Theoretical Biology·Ehsan Jabbarzadeh, Cameron F Abrams
Oct 11, 2005·Biophysical Journal·Alexandre SaezBenoît Ladoux
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Apr 12, 2006·Nature Reviews. Molecular Cell Biology·Viola Vogel, Michael Sheetz
Jun 24, 2006·Bulletin of Mathematical Biology·D G Mallet, G J Pettet
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Sep 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vikram S DeshpandeAnthony G Evans
May 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alexandre SaezBenoît Ladoux
May 31, 2007·The Journal of Cell Biology·Peter J M van HaastertArjan Kortholt
Jul 7, 2007·Methods in Cell Biology·Nathan J Sniadecki, Christopher S Chen
Aug 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Juan C Del AlamoJuan C Lasheras
Sep 18, 2007·Cell Biochemistry and Biophysics·Brendan FlahertyP E McHugh
Oct 18, 2007·Journal of the Royal Society, Interface·Amit PathakAnthony G Evans
Dec 20, 2007·Journal of Public Health Management and Practice : JPHMP·James C ThomasBrooke A Levandowski

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Citations

Aug 8, 2015·Medical & Biological Engineering & Computing·Yuxu Geng, Zhanjiang Wang
Jan 18, 2020·Advanced Healthcare Materials·Ava M ObenausNathan J Sniadecki

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