Cell migration is a highly regulated and complex cellular process to maintain proper homeostasis for various biological processes. Extracellular environment was identified as the main affecting factors determining the direction of cell crawling. It was observed experimentally that the cell prefers migrating to the area with denser or stiffer array of microposts. In this article, an integrated unidirectional cell crawling model was developed to investigate the spatiotemporal dynamics of unidirectional cell migration, which incorporates the dominating intracellular biochemical processes, biomechanical processes and the properties of extracellular micropost arrays. The interpost spacing and the stiffness of microposts are taken into account, respectively, to study the mechanism of unidirectional cell locomotion and the guidance of extracellular influence cues on the direction of unidirectional cell crawling. The model can explain adequately the unidirectional crawling phenomena observed in experiments such as "spatiotaxis" and "durotaxis," which allows us to obtain further insights into cell migration.
Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs
Real-time measurement of the contractile forces of self-organized cardiomyocytes on hybrid biopolymer microcantilevers
Development of micropost force sensor array with culture experiments for determination of cell traction forces
(De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.
Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.