PMID: 6972703Jul 1, 1981Paper

Unidirectional flux ratio for potassium ions in depolarized frog skeletal muscle

The American Journal of Physiology
B C SpaldingP Horowicz

Abstract

Small bundles of frog skeletal muscle fibers were loaded with 305 mM K+ and 120 mM Cl-, and 42K+ tracer efflux and influx were measured as a function of external K+ concentration ([K+]o) at a resting potential of -2 mV. As [K+]o was lowered from 305 mM, efflux decreased along a markedly sigmoidal curve, reaching a constant nonzero value at low [K+]o. Influx varied linearly with [K+]o at low [K+]o and more steeply at higher [K+]o. The ratio of influx to efflux was described by the equation: influx/efflux = exp[-n(V - VK)F/RT] with n = 2 at high [K+]o, but the ratio approached this equation with n = 1 at low [K+]o. Efflux did not depend on [K+]o when the membrane potential was raised to +36 mV, whereas at low [K+]o decreasing the membrane potential to -19 mV further activated the efflux. The results are discussed in terms of an inwardly rectifying potassium channel with two or more activating sites within the membrane that bind K+ and are accessible from the external solution.

References

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Citations

Jan 1, 1983·The Journal of Membrane Biology·R Latorre, C Miller
Jan 1, 1982·The Journal of Membrane Biology·B C SpaldingP Horowicz
Aug 29, 2001·The Journal of General Physiology·M LeMasurierC Miller
Jan 1, 1986·The Journal of Membrane Biology·B C SpaldingP Horowicz
Jan 1, 1986·The Journal of Membrane Biology·K E CooperR S Eisenberg
Oct 4, 2000·Physiological Reviews·O M Sejersted, G Sjøgaard
Jun 17, 2015·The Journal of General Physiology·Steve W Lockless
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·R MacKinnon
Jan 1, 1985·The Journal of Membrane Biology·B Vestergaard-BogindP Christophersen
Oct 6, 1998·The Journal of General Physiology·P StampeT Begenisich
Oct 24, 1997·Journal of Applied Physiology·S J Hong, C C Chang
Dec 17, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Boaz NadlerR S Eisenberg
May 24, 1991·Science·C Miller

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