Unified approach for multiple sclerosis lesion segmentation on brain MRI

Annals of Biomedical Engineering
Balasrinivasa Rao SajjaPonnada A Narayana

Abstract

The presence of large number of false lesion classification on segmented brain MR images is a major problem in the accurate determination of lesion volumes in multiple sclerosis (MS) brains. In order to minimize the false lesion classifications, a strategy that combines parametric and nonparametric techniques is developed and implemented. This approach uses the information from the proton density (PD)- and T2-weighted and fluid attenuation inversion recovery (FLAIR) images. This strategy involves CSF and lesion classification using the Parzen window classifier. Image processing, morphological operations, and ratio maps of PD- and T2-weighted images are used for minimizing false positives. Contextual information is exploited for minimizing the false negative lesion classifications using hidden Markov random field-expectation maximization (HMRF-EM) algorithm. Lesions are delineated using fuzzy connectivity. The performance of this algorithm is quantitatively evaluated on 23 MS patients. Similarity index, percentages of over, under, and correct estimations of lesions are computed by spatially comparing the results of present procedure with expert manual segmentation. The automated processing scheme detected 80% of the manually seg...Continue Reading

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Citations

May 18, 2011·Neuroradiology·Daryoush MortazaviHamid Soltanian-Zadeh
Jun 25, 2008·Annals of Biomedical Engineering·Renjie HePonnada A Narayana
Oct 14, 2011·The New England Journal of Medicine·Paul O'ConnorUNKNOWN TEMSO Trial Group
Sep 17, 2009·International Journal of Biomedical Imaging·Oren FreifeldJacob Goldberger
Sep 4, 2010·Multiple Sclerosis : Clinical and Laboratory Research·A H PoonawallaP A Narayana
May 6, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Flavia NelsonJerry S Wolinsky
Nov 17, 2010·PloS One·Xintian YuPonnada A Narayana
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Khader M HasanPonnada A Narayana
Jan 16, 2008·Radiology·Aziz H PoonawallaPonnada A Narayana
May 6, 2015·Acta Neurologica Scandinavica·L B LathamJ W Lindsey
Jan 27, 2009·Journal of the Neurological Sciences·Guozhi TaoPonnada A Narayana
Dec 11, 2008·Neuroimaging Clinics of North America·Mark A Horsfield
Sep 24, 2008·Revue neurologique·J-C SoupletG Malandain
Apr 5, 2008·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Renjie HePonnada A Narayana
Aug 16, 2011·NeuroImage·René A ColoradoPonnada A Narayana
Sep 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alex M PagnozziNicholas Dowson
Jun 23, 2015·Human Brain Mapping·Koushik A GovindarajanUNKNOWN CombiRx Investigators Group
Apr 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·Sushmita DattaPonnada A Narayana
Jan 14, 2012·Journal of Magnetic Resonance Imaging : JMRI·Khader M HasanPonnada A Narayana
Feb 21, 2013·Annals of Neurology·Fred D LublinUNKNOWN CombiRx Investigators
Mar 31, 2011·Journal of Magnetic Resonance Imaging : JMRI·Sushmita Datta, Ponnada A Narayana
Jan 11, 2013·International Journal for Numerical Methods in Biomedical Engineering·Jean-Baptiste FiotJurgen Fripp
Oct 2, 2012·Journal of Magnetic Resonance Imaging : JMRI·Shuangxi JiJing Fang
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Erin GibsonNancy J Lobaugh
Apr 8, 2015·IEEE Transactions on Medical Imaging·Carole H SudreSebastien Ourselin
Jul 18, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Shan ShenAnnette Sterr
Jul 6, 2010·IEEE Transactions on Bio-medical Engineering·Jon McAuslandDavid K B Li
Nov 26, 2015·Journal of Magnetic Resonance Imaging : JMRI·Mário João FartariaCristina Granziera
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Mar 20, 2015·Multiple Sclerosis and Related Disorders·Sushmita DattaUNKNOWN CombiRx Investigators Group
Nov 1, 2016·International Journal of Computer Assisted Radiology and Surgery·Refaat E GabrPonnada A Narayana

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