Unified disease, unified management: treating allergic rhinitis and asthma with nasally inhaled corticosteroid

Respiratory Medicine
Cláudia Ribeiro de AndradePaulo Augusto Camargos

Abstract

Persistent allergic rhinitis (AR) and asthma constitute a common comorbidity. Combined treatment is recommended by prescribing intranasal plus oral inhaled corticosteroids. This study was carried out to assess the efficacy of an alternative regimen to treat this condition. All recruited patients suffered from persistent AR and asthma. Diagnosis and classification of AR and asthma were based on international guidelines. The experimental group received fluticasone propionate (FP), 500microg/day during six weeks, inhaled exclusively through the nose using a valved large volume spacer attached to a face mask. The comparison group also received the same dose of orally inhaled FP, during the same time period, plus intranasal aqueous fluticasone, 200microg/day. There were no statistical differences between both groups regarding AR and asthma severity, clinical scores, acoustic rhinometry, lung function, and FeNO upon admission and during the follow up period. Intragroup analysis demonstrated a significant improvement for allergic rhinitis and asthma scores as well as for FeNO from admission to the sixth week (p<0.01) in both groups. Results suggest that exclusive nasally inhaled fluticasone propionate should be considered as an altern...Continue Reading

References

Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·M J RosierP D Phelan
May 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M WilsonB J Lipworth
Jul 27, 2004·Pediatric Pulmonology·Paulo A M CamargosLaura M L B F Lasmar
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society

❮ Previous
Next ❯

Citations

Aug 21, 2013·Paediatric Drugs·Olympia A TsilochristouNikolaos G Papadopoulos
Apr 21, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K MatsunagaM Ichinose
Oct 27, 2012·Respiratory Medicine·UNKNOWN Inhaler Error Steering CommitteeJ Bousquet
Mar 19, 2014·Otolaryngologia polska. The Polish otolaryngology·Bolesław SamolińskiAneta Tomaszewska
Aug 14, 2012·Current Opinion in Allergy and Clinical Immunology·Marie-Eve BoulayLouis-Philippe Boulet
Oct 7, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Asako OkaKazuto Matsunaga
Jun 4, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery
Jul 2, 2011·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.