Unified nexus of macrophages and maresins in cardiac reparative mechanisms

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jeevan Kumar Jadapalli, Ganesh V Halade

Abstract

Macrophages are immune-sensing "big eater" phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase-mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR-1, produced by human macrophages, has potent defining effects that limit polymorphonuclear neutrophil infiltration, enhance uptake of apoptotic PMNs, regulate inflammation resolution and tissue regeneration, and reduce pain. In addition to proresolving and anti-inflammatory actions, MaR-1 displays potent tissue regenerative effects in stroke and is an antinociceptive. Macrophages actively participate in the biosynthesis of bioactive MaR-2, which exhibits anti-inflammatory, proresolving, and atherosclerotic effects. A new class of macrophage-derived molecules, MaR conjugates in tissue regeneration, is identified that regulates phagocytosis and the repair and regeneration of damaged tissue. The presented review provides a current summary of the ...Continue Reading

References

Mar 8, 1974·Nature·R O BeckerR Sherry
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Massimo LocatiAlberto Mantovani
Dec 14, 2002·Science·Kenneth D PossMark T Keating
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS
Dec 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Krishnaprasad SubbaraoBodduluri Haribabu
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick PerrierAlberto Mantovani
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris J ScottonSilvano Sozzani
Jan 25, 2006·Autoimmunity Reviews·Martina Prelog
Jan 24, 2007·The Journal of Experimental Medicine·Sabrina GrossJean-Etienne Fabre
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Makoto AritaCharles N Serhan
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Jun 19, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aksam J MerchedLawrence Chan
Nov 29, 2008·European Journal of Immunology·Siamon Gordon
Dec 24, 2008·The Journal of Experimental Medicine·Charles N SerhanMatthew Spite
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eliver Eid Bou GhosnLeonore A Herzenberg
Mar 26, 2010·Nature·Chris JoplingJuan Carlos Izpisúa Belmonte
Feb 26, 2011·Science·Enzo R PorrelloHesham A Sadek
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanNicos A Petasis
Mar 24, 2012·Science·Christian SchulzFrederic Geissmann
Feb 22, 2013·Aging·Bernhard Johannes HaubnerJosef M Penninger
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Norbert Leitinger, Ira G Schulman
May 7, 2013·Journal of Molecular and Cellular Cardiology·Xiaoxiang YanMotoaki Sano
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jesmond DalliMauro Perretti
May 28, 2013·Cellular and Molecular Life Sciences : CMLS·Igor M Samokhvalov
May 28, 2013·Nature·Tim LämmermannRonald N Germain
Jun 12, 2013·Current Opinion in Pharmacology·Charles N Serhan, Nan Chiang
Aug 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yi FangKenneth D Poss
Aug 30, 2013·Science Translational Medicine·Wen TianMark R Nicolls
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodrigo MarconJoão B Calixto

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Citations

Dec 12, 2018·American Journal of Physiology. Endocrinology and Metabolism·Yong LiuJianbo Wu
Aug 23, 2018·Basic Research in Cardiology·Kristine Y DeLeon-PennellMerry L Lindsey
Dec 14, 2018·Basic Research in Cardiology·Mira JungThomas Thum
Nov 27, 2019·International Journal of Molecular Sciences·Sung-Min HwangChul-Kyu Park
May 27, 2021·American Journal of Physiology. Cell Physiology·Tri WahyuniYasushi Fujio

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