Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation

PLoS Computational Biology
Guoshi LiFlavio Fröhlich

Abstract

The thalamus plays a critical role in the genesis of thalamocortical oscillations, yet the underlying mechanisms remain elusive. To understand whether the isolated thalamus can generate multiple distinct oscillations, we developed a biophysical thalamic model to test the hypothesis that generation of and transition between distinct thalamic oscillations can be explained as a function of neuromodulation by acetylcholine (ACh) and norepinephrine (NE) and afferent synaptic excitation. Indeed, the model exhibited four distinct thalamic rhythms (delta, sleep spindle, alpha and gamma oscillations) that span the physiological states corresponding to different arousal levels from deep sleep to focused attention. Our simulation results indicate that generation of these distinct thalamic oscillations is a result of both intrinsic oscillatory cellular properties and specific network connectivity patterns. We then systematically varied the ACh/NE and input levels to generate a complete map of the different oscillatory states and their transitions. Lastly, we applied periodic stimulation to the thalamic network and found that entrainment of thalamic oscillations is highly state-dependent. Our results support the hypothesis that ACh/NE modul...Continue Reading

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Citations

Nov 20, 2018·The European Journal of Neuroscience·Ehsan NegahbaniFlavio Fröhlich
Aug 31, 2019·Annals of Clinical and Translational Neurology·Diana PizarroSandipan Pati
Aug 28, 2020·Frontiers in Neural Circuits·Max Bennett
Oct 6, 2020·Frontiers in Computational Neuroscience·Hiroshi Yamakawa
Feb 11, 2020·Frontiers in Computational Neuroscience·Qiang LiRui Zhang
Dec 14, 2018·Journal of Neural Engineering·Guoshi LiFlavio Fröhlich
Nov 6, 2018·Chaos·Noah Holmgren HopkinsSvetlana Postnova
Jun 6, 2021·Brain Topography·Matteo SaponatiAlberto Mazzoni

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