Uniform carboxymethyl chitosan-enveloped Pluronic F68/poly(lactic-co-glycolic acid) nano-vehicles for facilitated oral delivery of gefitinib, a poorly soluble antitumor compound

Colloids and Surfaces. B, Biointerfaces
Jing WangYanzhuo Zhang

Abstract

In this study, a new type of biodegradable and stable carboxymethyl chitosan (CCS)-enveloped Pluronic® F68/poly(lactic-co-glycolic acid) (PF/PLGA) nanoparticle (CCS/PF/PLGA NP) was developed, and its potential as an oral delivery vehicle to achieve pH-triggered prolonged release, enhance cellular uptake, and promote oral absorption of poorly soluble antitumor compounds was systemically studied. In this nanocarrier, a PF/PLGA NP serves as the core for effective loading, transport, and prolonged release of a chemotherapeutic agent, while a CCS surface layer acts as the shell and provides pH-responsive and mucoadhesive features. Gefitinib (GEF), an oral poorly soluble chemotherapeutic agent, was selected as the model compound. The prepared GEF-loaded CCS/PF/PLGA (GEF/CCS/PF/PLGA) NPs possessed a monodispersed spherical shape with a uniform size (242 ± 6 nm). Thermal analysis confirmed that GEF/CCS/PF/PLGA NPs were present in an amorphous form. Drug release tests showed that GEF/CCS/PF/PLGA NPs have a pH-responsive prolonged release manner with limited drug release at low gastric pH. Furthermore, the mucoadhesive property, intestinal distribution, cellular uptake, and cytotoxicity of CCS/PF/PLGA NPs were also tested. After oral adm...Continue Reading

Citations

Jun 5, 2019·Journal of Biomedical Materials Research. Part a·Ting LiJianhua Wang
Dec 19, 2020·International Journal of Biological Macromolecules·Sheersha Pramanik, Vaishnavi Sali
Dec 16, 2020·Colloids and Surfaces. B, Biointerfaces·XinHong GuoZhenZhong Zhang
Jul 31, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjun WangHuiling Hu
Mar 8, 2019·Biomacromolecules·Yanbo ZhangXuesi Chen
Jan 27, 2022·Journal of Drug Targeting·Zhongxiao LinXi-Yong Yu

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