Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging

ACS Applied Materials & Interfaces
Sijia XuDecheng Wu

Abstract

Well-designed agents for enhanced multimodal imaging have attracted great interests in recent years. In this work, we adopted a premix membrane emulsification (PME) method to prepare uniform PEGylated poly(lactic-co-glycolic acid) (PLGA) microcapsules (MCs) with superparamagnetic Fe3O4 nanoparticles (NPs) embedded in the shell (Fe3O4@PEG-PLGA MCs) for ultrasound (US)/magnetic resonance (MR) bimodal imaging. Compared to Fe3O4@PLGA MCs without PEGylation, Fe3O4@PEG-PLGA MCs could more stably and homogeneously disperse in physiological solutions. In vitro and in vivo trials demonstrated that Fe3O4@PEG-PLGA MCs (∼3.7 μm) with very narrow size distribution (PDI=0.03) could function as efficient dual-modality contrast agents to simultaneously enhance US and MR imaging performance greatly. In vitro cell toxicity and careful histological examinations illustrated no appreciable cytotoxicity and embolism of Fe3O4@PEG-PLGA MCs to mice even at high dose. The uniform composite MCs developed here can act as clinical bimodal contrast agents to improve hybrid US/MR imaging contrast, which is promising for accurate diagnosis and real-time monitoring of difficult and complicated diseases.

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Citations

Jun 9, 2016·Toxicology Research·Crystal S LewisStella E Tsirka
Jun 30, 2016·Nanoscale·Shatadru ChakravartyErik M Shapiro
Oct 19, 2019·Tissue Engineering and Regenerative Medicine·Shameer PillarisettiIn-Kyu Park
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Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Da HuangDecheng Wu
Aug 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sijia XuDecheng Wu
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Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jingxin WangLining Zhang
Apr 10, 2021·Cytotherapy·Brooke M HelferWilliam D Shingleton
Apr 12, 2018·ACS Applied Materials & Interfaces·Ruyuan SongShuhuai Yao

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