Unifying treatments for depression: an application of the Free Energy Principle

Frontiers in Psychology
Adam M Chekroud

Abstract

Major Depressive Disorder is a debilitating and increasingly prevalent psychiatric condition (Compton et al., 2006; Andersen et al., 2011). At present, its primary treatments are antidepressant medications and psychotherapy. Curiously, although the pharmacological effects of antidepressants manifest within hours, remission of clinical symptoms takes a number of weeks-if at all. Independently, support has grown for an idea-proposed as early as Helmholtz (von Helmholtz, 1924)-that the brain is a prediction machine, holding generative models for the purpose of inferring causes of sensory information (Dayan et al., 1995; Rao and Ballard, 1999; Knill and Pouget, 2004; Friston et al., 2006; Friston, 2010). If the brain does indeed represent a collection of beliefs about the causal structure of the world, then the depressed phenotype may emerge from a collection of depressive beliefs. These beliefs are modified gradually through successive combinations of expectations with observations. As a result, phenotypic remission ought to take some time as the brain's relevant statistical structures become less pessimistic.

References

Dec 1, 1979·Journal of Experimental Psychology. General·L B Alloy, L Y Abramson
Sep 1, 1995·Neural Computation·P DayanR S Zemel
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Mar 14, 1997·Science·W SchultzP R Montague
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Nov 16, 2004·Trends in Neurosciences·David C Knill, Alexandre Pouget
Feb 11, 2005·Journal of Experimental Psychology. General·Rachel M MsetfiDiana E Kornbrot
Mar 2, 2005·Nature Reviews. Neuroscience·Eero Castrén
Mar 24, 2006·The New England Journal of Medicine·A John RushUNKNOWN STAR*D Study Team
Mar 24, 2006·The New England Journal of Medicine·Madhukar H TrivediUNKNOWN STAR*D Study Team
Nov 14, 2006·Journal of Physiology, Paris·Karl FristonLee Harrison
Jun 26, 2007·Brain : a Journal of Neurology·J D SteeleK P Ebmeier
Aug 7, 2007·Nature Neuroscience·Timothy E J BehrensMatthew F S Rushworth
Aug 19, 2007·Journal of Abnormal Psychology·Xavier CaserasKarin Mogg
Jun 27, 2008·Brain : a Journal of Neurology·P KumarJ D Steele
Nov 14, 2008·Nature·Timothy E J BehrensMatthew F S Rushworth
Dec 4, 2008·Nature Reviews. Neuroscience·Paul C Fletcher, Chris D Frith
Mar 17, 2009·Cognition·Quentin J M Huys, Peter Dayan
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karl Friston, Stefan Kiebel
Jul 31, 2009·PloS One·Karl J FristonStefan J Kiebel
Nov 10, 2009·Biological Psychiatry·Marije aan het RotSanjay J Mathew
Jan 14, 2010·Nature Reviews. Neuroscience·Karl Friston
Mar 26, 2010·Depression and Anxiety·Gabriel S DichterJames C Garbutt
Jul 16, 2010·Psychopharmacology·Henry W ChaseTrevor W Robbins
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip R CorlettPaul C Fletcher
Apr 12, 2011·Cognitive Neuropsychiatry·Michael MoutoussisPeter Dayan
Apr 13, 2011·Brain : a Journal of Neurology·Victoria B GradinJ Douglas Steele
Jun 2, 2011·Frontiers in Human Neuroscience·Christoph MathysKlaas E Stephan
Oct 4, 2011·Scandinavian Journal of Public Health·Ingelise AndersenFinn Diderichsen
Dec 20, 2011·Trends in Cognitive Sciences·P Read MontaguePeter Dayan
Jan 14, 2012·PLoS Computational Biology·Karl J FristonSven Bestmann
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ben SeymourRay Dolan
Jun 19, 2012·Biological Psychiatry·Marije Aan Het RotSanjay J Mathew
Jun 22, 2012·Clinical Psychology Review·Michael T Moore, David M Fresco
Sep 18, 2012·Trends in Cognitive Sciences·Wei Ji Ma
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Catherine J Harmer, Philip J Cowen
May 15, 2013·The Behavioral and Brain Sciences·Andy Clark
Jun 12, 2013·Frontiers in Psychiatry·Rick A AdamsKarl J Friston
Jun 21, 2013·Biology of Mood & Anxiety Disorders·Quentin Jm HuysPeter Dayan
Jun 21, 2013·PLoS Computational Biology·Mateus Joffily, Giorgio Coricelli

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Citations

Sep 27, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ali AhmedF Cleveland Kinney
Nov 7, 2016·Brain and Cognition·Lucy S Petro, Lars Muckli
Feb 27, 2018·Psychological Medicine·James E ClarkKarl J Friston
May 23, 2019·Cognitive, Affective & Behavioral Neuroscience·Paul B BadcockJakob Hohwy
Jun 22, 2019·Pharmacological Reviews·R L Carhart-Harris, K J Friston
Aug 30, 2020·Psychiatry and Clinical Neurosciences·Ryan SmithKarl J Friston
Nov 2, 2018·Computational Psychiatry·Aaron ProsserThomas Parr
Jul 28, 2020·Frontiers in Psychology·Valery Krupnik
Dec 10, 2019·Neuroscience and Biobehavioral Reviews·Jasmine T HoBigna Lenggenhager
May 22, 2021·Brain and Neuroscience Advances·Joost HaarsmaSandra Tamm
Dec 8, 2021·Scientific Reports·Andreas StrubeChristian Büchel

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