PMID: 8960704Nov 1, 1996Paper

Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep

Experimental Physiology
P J MooreM A Hanson

Abstract

In nineteen alpha-chloralose-anaesthetized 3- to 8-day-old lambs, the effect of cooling focally in the region of the locus coeruleus on respiratory output, as measured from phrenic nerve activity, was examined during normoxia and isocapnic hypoxia, and during infusion of adenosine or saline. Eleven lambs showed a 'biphasic' respiratory response to hypoxia, with an initial increase in phrenic nerve activity (phase 1) being followed by a decline to prehypoxic levels (phase 2). Cooling to 26-34 degrees C unilaterally in the locus coeruleus reversed the fall in respiratory output. When the probe temperature was returned to body temperature (39 degrees C) respiratory output fell again to phase 2 levels. Cooling had no effect during normoxia. In these lambs, adenosine infusion (0.3 mg kg-1 min-1 intra-arterially) during normoxia also decreased respiratory output. During adenosine infusion, cooling again increased respiratory output. Saline infusion did not affect respiratory output during normoxia with or without cooling. The other lambs did not show a biphasic respiratory response, i.e. increased respiratory output was maintained during isocapnic hypoxia. In these lambs adenosine had no effect on respiratory output. Cooling/rewarmin...Continue Reading

Citations

Jul 20, 2002·Respiratory Physiology & Neurobiology·Sophie AizenfiszJorge Gallego
May 5, 2004·Respiratory Physiology & Neurobiology·Caroline M FerreiraLuiz G S Branco
Jan 4, 1998·Respiration Physiology·G L AcklandM A Hanson
Mar 31, 2004·Seminars in Neonatology : SN·Estelle B GaudaDaniel Kwak
Jun 12, 2012·Respiratory Physiology & Neurobiology·Robert A Darnall
May 4, 2010·Respiratory Physiology & Neurobiology·Luciane H GargaglioniRobert W Putnam
Dec 23, 2009·Respiratory Physiology & Neurobiology·Vivian BiancardiLuciane H Gargaglioni
Jun 14, 2008·Respiratory Physiology & Neurobiology·Luciane H GargaglioniLuiz Guilherme S Branco
Mar 19, 2013·Autonomic Neuroscience : Basic & Clinical·Alfredo J GarciaJan-Marino Ramirez
Nov 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G FabrisL G Branco
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Aug 14, 2019·Experimental Physiology·Michael George Zaki Ghali
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M Bissonnette
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J KoosL Kruger
Dec 9, 2003·Journal of Applied Physiology·Judith A Neubauer, Jagadeeshan Sunderram
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Jan 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J KoosLawrence Kruger
May 20, 1998·Journal of Neurophysiology·B J KoosL Kruger
Aug 25, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H GargaglioniLuis Gustavo A Patrone
Aug 21, 2007·The Journal of Experimental Biology·Stéphanie FournierRichard Kinkead
Sep 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R KinkeadG S Mitchell

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