PMID: 2278132Nov 1, 1990Paper

Unilateral degeneration of retina and optic nerve in Fischer-344 rats

Veterinary Pathology
E W LeeL C Li


Unilateral degeneration of the retina and optic nerve was observed among Fischer-344 (F-344) rats fed a semi-purified synthetic feed. Further studies were conducted using standard cereal-based and synthetic diets. Beginning at 4 weeks of age, all experimental rats (169 F-344 rats) were fed various diets and were examined for morphologic and functional changes in the retina and optic nerve. No ocular lesions were observed in any F-344 rats prior to 21 weeks of age, whether fed a synthetic diet or a standard diet; however, approximately 16% (13/86) of the F-344 rats examined between 57 and 64 weeks of age developed unilateral degeneration of the retina and optic nerve. On the other hand, the F-344 rats fed the synthetic diet developed the degenerative lesions by 30 weeks of age, while the F-344 rats fed the standard diet did not develop lesions over this shorter time period. Degenerative changes of the affected retinas and optic nerves were closely related with functional abnormalities evaluated by electroretinogram and visual evoked potentials. In contrast with the F-344 rats, Long-Evans rats that were fed either the synthetic or standard diet up to the age of 68 weeks (77 rats) did not develop the ocular lesions. There was no a...Continue Reading


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Jun 1, 1983·Brain Research Bulletin·W K Boyes, R S Dyer
Jan 1, 1982·Ophthalmic Research·R E SchmidtP S O'Connor
Jan 1, 1981·Journal of Neuropathology and Experimental Neurology·A PrivatJ Fulcrand
Aug 1, 1963·Archives of Ophthalmology·C KUPFER


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Related Concepts

Visual Evoked Cortical Potential
Nerve Degeneration
Optic Nerve
Rats, Inbred F344
Retinal Degeneration
Rodent Diseases

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