Unilateral eye enucleation in adult rats causes neuronal loss in the contralateral superior colliculus

Journal of Anatomy
S A Smith, K S Bedi

Abstract

Several studies have reported the morphological changes induced by unilateral enucleation during early neonatal life on the developing visual system. This study has examined cellular changes in the superior colliculi by removal of a single eye in adult rats. Anaesthetised male hooded rats aged 90 d had their right eyes removed. Groups of nonenucleated control and enucleated rats were killed when aged either 150 or 390 d. The brains were removed and both the right and left superior colliculi dissected out. The volume of the stratum griseum superficiale (SGS) within these colliculi was estimated stereologically by light microscopy, as well as the numerical density and total number of neurons within this cell layer. The volume of the cell layer was reduced by about 40% on the side contralateral to the enucleated eye but not on the ipsilateral side at both survival periods examined. The numerical density of neurons within the SGS was unaffected by the enucleation so that the colliculi contralateral to the enucleated eye showed a substantial loss of neurons within this cells layer. This study demonstrates the importance of the retinal ganglion cell input, even in adult animals, for maintaining the viability of neurons in the SGS lay...Continue Reading

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Citations

Mar 14, 2009·Experimental Brain Research·Jennifer Rodger, Douglas O Frost
Dec 4, 2003·Brain Research. Developmental Brain Research·Nurhan ConSuleyman Kaplan
May 30, 2001·Brain Research·E G Marchant, L P Morin
Sep 27, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marucia ChacurLuiz R G Britto
Dec 18, 2013·Brain Research Bulletin·Marina S Hernandes, Luiz R G Britto
May 29, 2012·Neuroscience Letters·Marina S HernandesLuiz R G Britto
Jan 7, 2015·Brain Structure & Function·Luca CecchettiPietro Pietrini
Nov 6, 2003·Microscopy Research and Technique·Florentina DíazIgnacio Pérez De Vargas
Oct 29, 2020·The European Journal of Neuroscience·Sara ToujMathieu Piché

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