Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw

British Journal of Pharmacology
I BileviciuteT Lundeberg

Abstract

The contribution of calcitonin gene-related peptide (CGRP) to bilateral oedema formation in the rat hindpaw following an unilateral challenge with CGRP was investigated. Rats were injected into the left hindpaw with either saline, CGRP or a CGRP antagonist (CGRP8-37). All injections were given in a double blind fashion and in a volume of 100 microl. CGRP and CGRP8-37 were administered in concentrations of 75, 150 or 300 pmol. Volumes of the right and left hindpaw were measured every hour for 5 h by plethysmometry. Injection of CGRP 300 pmol into the left hindpaw resulted in a bilaterally increased hindpaw volume after 5 h as compared with the groups given saline. No changes were found in hindpaw volumes following the injection of either 75 or 150 pmol of CGRP or 75, 150 or 300 pmol of CGRP8-37 as compared with saline injection. To elucidate whether or not the bilateral oedema formation was related to a release of endogenous CGRP, microdialysis of the contralateral hindpaw was carried out, and concentrations of CGRP-like immunoreactivity (-LI) were determined by radioimmunoassay and high performance liquid chromatography. Injection of CGRP 300 pmol into the left hindpaw increased the release of CGRP-LI into the right hindpaw per...Continue Reading

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Citations

Oct 26, 1999·Trends in Neurosciences·L F Donaldson
Aug 12, 2014·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Bruno MagnanElena Samaila
Oct 19, 2011·European Journal of Pharmacology·Sara Marchesan OliveiraJuliano Ferreira
Dec 18, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roxanne Y WalderKathleen A Sluka
Feb 10, 2019·International Journal of Molecular Sciences·Shaista AfrozYoshizo Matsuka
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E Gouze-DecarisB Terlain
Apr 17, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jeffri S RetamalPeter McIntyre

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