Unilateral ovariectomy increases inhibin messenger ribonucleic acid levels in newly recruited follicles

Endocrinology
J D'AgostinoN B Schwartz

Abstract

We have used the unilaterally ovariectomized (ULO) rat as an experimental model to assess transient relationships between follicular recruitment and inhibin mRNA levels in the ovary. Animals were divided into three experimental groups (ULO, sham-operated, and intact) and killed 0, 9, or 24 h postsurgery. Inhibin alpha- and beta A mRNA were measured within individual ovarian follicles by in situ hybridization. Serum FSH concentrations in ULO animals increased significantly at 9 h and returned to presurgery levels by 24 h. There was no effect of surgery on serum LH concentrations. In the ULO animals, compensatory follicular recruitment was observed in the remaining ovary at 24 h as a significant increase in the number of follicles with mean diameter greater than 350 micron. Two distinct populations of healthy maturing follicles, based on diameter and hybridization intensity, were observed in ovaries from 24 h post-ULO rats. The first class, NRF-1 (newly recruited follicle-1), were those recruited 48 h previously by the secondary FSH surge of the preceding cycle. These large follicles (greater than 500 micron mean diameter) hybridized to both inhibin probes. The second class of follicles (NRF-2), which represent those newly recrui...Continue Reading

Citations

Dec 26, 2001·The Journal of Experimental Zoology·Ermelinda LimatolaMaurizio Romano
Oct 29, 2002·Reproductive Toxicology·M B Hiremath, B B Kaliwal
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Rachel C HirstHarry M Charlton
Aug 20, 2010·Systems Biology in Reproductive Medicine·Yunus AydinCagnur Ulukus
Nov 30, 2007·Biology of Reproduction·R DuggavathiN C Rawlings
Jul 23, 2014·Endocrine Reviews·Yogeshwar MakanjiTeresa K Woodruff

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