PMID: 1186119Oct 1, 1975Paper

Unilateral renovascular hypertension in rats. Measurements of medullary granules, juxtaglomerular granularity and cellularity, and areas of adrenal zones.

Laboratory Investigation; a Journal of Technical Methods and Pathology
H LattaW H Johnston

Abstract

To produce hypertension, the left renal artery was clipped in 20 rats. Six rats had a sham operation. After 4 months, some of the rats showed only a moderate increase in blood pressure, and a second clipping of the same artery was performed. When hypertension became severe in some of the rats, 2 to 4 weeks later, all rats were sacrificed. The "clipped" rats were divided into four groups depending on whether they had little change in blood pressure, acute hypertension, chronic hypertension, or chronic and superimposed acute hypertension. The average adrenal weights were increased in the two groups with acute hypertension. The area of the adrenal glomerular zone was increased in all three groups with hypertension. The groups with acute hypertension also showed increases in the combined areas of (1) the medullary and androgenic zones and possibly (2) the fascicular and reticular zones. The granules of the left juxtaglomerular apparatus were greatly increased in the group with acute hypertension, but were only slightly elevated in the group with chronic hypertension and the group with chronic and superimposed acute hypertension. An increased juxtaglomerular cellularity in the clipped kidney correlated best with hypertension. Renal ...Continue Reading

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.