Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma

Asia-Pacific Journal of Ophthalmology
Carol L ShieldsJerry A Shields

Abstract

The objective of this study was to compare outcomes after intravenous chemotherapy (IVC) versus intra-arterial chemotherapy (IAC) for unilateral retinoblastoma. A retrospective comparative interventional case series. Patients with unilateral retinoblastoma managed with either IVC using vincristine, etoposide, and carboplatin or IAC using melphalan with or without topotecan with a minimum of 1-year follow-up were compared. The primary outcome measure was globe salvage. Of 91 patients with unilateral retinoblastoma, IVC was employed in 42 (46%) cases and IAC in 49 (54%). By comparison (IVC vs IAC), patients in the IAC group had greater mean tumor diameter (14 vs 18 mm, P < 0.001) and thickness (7 vs 10 mm, P = 0.001), greater percentage with active vitreous seeds (29% vs 55%, P = 0.01), and greater total retinal detachment (10% vs 43%, P < 0.001). There were no cases of group A in either treatment arm. Globe salvage was not significantly different in groups B, C, or E, but there was significantly improved globe salvage with IAC for group D (48% vs 91%, P = 0.004). Control was significantly better with IAC for solid tumor (62% vs 92%, P = 0.002), subretinal seeds (31% vs 86%, P = 0.006), and vitreous seeds (25% vs 74%, P = 0.006)....Continue Reading

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Citations

Jun 25, 2017·Pediatric Blood & Cancer·Jesse L BerryJonathan W Kim
Jan 13, 2018·Oncogene·Ido D FabianMandeep S Sagoo
Jun 18, 2017·Indian Journal of Pediatrics·Raksha Rao, Santosh G Honavar
Feb 12, 2017·The British Journal of Ophthalmology·Ido Didi FabianFrancis L Munier
Jul 21, 2020·Journal of Pediatric Ophthalmology and Strabismus·Lauren A DalvinCarol L Shields
Apr 12, 2020·Journal of Neurointerventional Surgery·Ahmad SweidPascal Jabbour
Nov 7, 2019·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Babak MasoomianCarol L Shields
Jul 2, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hayyam KiratliCanan Akyüz
Jun 27, 2020·AJNR. American Journal of Neuroradiology·A SweidP Jabbour
Sep 24, 2020·European Journal of Ophthalmology·Ibadulla MirzayevNurdan Taçyıldız
May 8, 2020·Eye·Ahmet Kaan GündüzMehmed Uğur Işık
May 15, 2018·F1000Research·Amy C Schefler, Ryan S Kim
Oct 31, 2020·Indian Journal of Ophthalmology·David Ancona-LezamaCarol L Shields
May 6, 2021·Japanese Journal of Ophthalmology·Pei-Ying ChenChun-Hsiu Liu
May 28, 2021·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Carol L ShieldsPascal Jabbour
Jul 3, 2021·NeoReviews·Monica ManriqueJana Bregman
Dec 21, 2021·Journal of Pediatric Ophthalmology and Strabismus·Megan RubenCarol L Shields

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