Unilateral vs bilateral sacral neuromodulation in pigs with formalin-induced detrusor hyperactivity

BJU International
Sascha KaufmannChristof van der Horst

Abstract

To investigate the efficacy of unilateral vs bilateral sacral neuromodulation (SNM) under standard experimental conditions by stimulating the dorsal sacral roots in pigs with formalin-induced detrusor hyperactivity. After lumbosacral laminectomy in eight alpha-chloralose-anaesthetized Göttinger mini-pigs, the dorsal roots of the nerve S3 were inserted into separate compartments of a size-modified Brindley electrode. Detrusor hyperactivity was induced by intravesical instillation of a 0.25% formalin solution. Stimulation of the separated dorsal roots was performed on the unilateral right, respectively, the unilateral left side, as well as bilaterally and with stimulation off-phases in a randomized pattern. A biphasic rectangular signal (impulse 200 micros, 20 Hz, 2.0 V) was used for SNM. The bladder pressure values were registered on a urodynamic unit and evaluated as contractions and amplitudes per minute. During unilateral stimulation, the mean (sem) number of contractions was reduced significantly from 4.73 (0.66) to 2.73 (0.62). The amplitude was also reduced significantly from 12.86 (1.23) to 8.32 (0.66). By contrast, bilateral stimulation lowered the mean (sem) number of overactive detrusor contractions to 1.08 (1.02) and ...Continue Reading

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Citations

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