Unimpaired allorejection of cells deficient for the mannose 6-phosphate receptors Mpr300 and Mpr46

Transplantation
Ralf DresselEberhard Günther

Abstract

Cytotoxic T lymphocytes (CTL) play an important role in the rejection of allogeneic cells and organs. CTL secrete granzymes and perforin as cytotoxic effector molecules. The mannose 6-phosphate receptor (Mpr)300 has been reported to function as receptor for granzyme B on target cells and to be essential for the rejection of allogeneic cells in vivo. Using mouse embryonal fibroblasts from Mpr300 and Mpr46 knockout mice, we show that both Mpr 300 and Mpr46 are dispensable on target cells for lysis and apoptosis mediated by alloreactive CTL in vitro and for allorejection in vivo. In agreement with a postulated function of Mpr300 as a tumor suppressor gene, deficiency of Mpr300 appears to promote cellular proliferation and tumorigenicity but not resistance to allorejection.

References

May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshihiko OkaRandy L Jirtle
Jan 23, 2003·The Journal of Cell Biology·Joseph A TrapaniKylie A Browne
Aug 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tania SimonCaner Süsal
Feb 27, 2004·The Journal of Biological Chemistry·Ralf DresselEberhard Günther

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Citations

Nov 14, 2006·Immunology Letters·Marcus LettauOttmar Janssen
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Carolyn D Scott, Wieland Kiess
Mar 25, 2005·The Journal of Biological Chemistry·Srikumar M RajaChristopher J Froelich

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