Unintended effects of drug carriers: Big issues of small particles

Advanced Drug Delivery Reviews
Hamideh ParhizVladimir R Muzykantov

Abstract

Humoral and cellular host defense mechanisms including diverse phagocytes, leukocytes, and immune cells have evolved over millions of years to protect the body from microbes and other external and internal threats. These policing forces recognize engineered sub-micron drug delivery systems (DDS) as such a threat, and react accordingly. This leads to impediment of the therapeutic action, extensively studied and discussed in the literature. Here, we focus on side effects of DDS interactions with host defenses. We argue that for nanomedicine to reach its clinical potential, the field must redouble its efforts in understanding the interaction between drug delivery systems and the host defenses, so that we can engineer safer interventions with the greatest potential for clinical success.

References

Sep 14, 1990·Journal of Immunological Methods·Y Aida, M J Pabst
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D Aragnol, L D Leserman
Nov 1, 1986·Journal of Leukocyte Biology·E B Wheeldon, J H Hansen-Flaschen
Nov 1, 1987·Journal of Applied Physiology·C M DoerschukJ C Hogg
Sep 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J A HaxbyS C Kinsky
Apr 1, 1983·Mutation Research·E GockeM T King
Sep 1, 1994·Mutation Research·I D AdlerG Schriever-Schwemmer
Jul 7, 1995·The Journal of Biological Chemistry·A RigottiM Krieger
Jan 1, 1995·Pharmaceutical Biotechnology·J Kreuter
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BoussifJ P Behr
Aug 1, 1993·Human Immunology·X M WangS Hardy
Mar 1, 1996·Clinics in Chest Medicine·A E Warner
Jun 12, 1996·Mutation Research·M KlaudeG Ahnström
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·B X ChenB F Erlanger
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A A RagabE M Greenfield
Sep 23, 2000·International Journal of Pharmaceutics·T IshidaH Kiwada
Dec 13, 2000·Mutation Research·A Russo
Jun 27, 2001·Survey of Ophthalmology·K R Wilhelmus
Feb 28, 2002·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Wolfgang M Kuebler, Alwin E Goetz
Jun 20, 2002·Trends in Immunology·Martha Triantafilou, Kathy Triantafilou
Jan 7, 2003·Nature Medicine·Peter J Hudson, Christelle Souriau
Apr 10, 2003·Free Radical Biology & Medicine·Thomas D SweitzerVladimir R Muzykantov
Jul 25, 2003·American Journal of Physiology. Cell Physiology·Silvia MuroMichael Koval
Oct 14, 2003·International Journal of Toxicology·Robert E Osterberg, Norman A See
Jan 13, 2004·Methods in Enzymology·Janos SzebeniCarl R Alving
Jan 23, 2004·Chemical Communications : Chem Comm·Davide PantarottoAlberto Bianco
Feb 21, 2004·British Journal of Cancer·J S KlooverJ P van Meerbeeck
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jeffrey S SmithAndrew P Byrnes
Aug 24, 2004·Current Vascular Pharmacology·Silvia MuroVladimir Muzykantov
Sep 2, 2004·Cell·Marcelo EhrlichTomas Kirchhausen
Sep 14, 2004·Biomacromolecules·Paul DalhaimerDennis E Discher
Nov 9, 2004·Current Opinion in Cell Biology·Rammohan V Rao, Dale E Bredesen
Nov 30, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ken-ichi OgawaraToshikiro Kimura
Jan 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Edward W CarneyJohn M DeSesso
Jun 1, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·S Moein MoghimiAdam Szewczyk
Aug 16, 2005·International Journal of Pharmaceutics·T M Göppert, R H Müller
Sep 10, 2005·Nature Biotechnology·Philipp Holliger, Peter J Hudson
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Feb 4, 2006·Science·Andre NelNing Li

❮ Previous
Next ❯

Citations

Dec 26, 2018·Current Topics in Medicinal Chemistry·Dinler A AntunesLydia E Kavraki
Mar 22, 2020·Pharmaceutics·Larisa KolevaElena Sinauridze
Apr 25, 2020·Polymers·Tanja NarancicKevin E O'Connor
Sep 5, 2020·Pharmaceutics·Shi Su, Peter M Kang
Aug 21, 2020·Toxicologic Pathology·Zaher A Radi, Thomas A Wynn
Oct 6, 2020·Advanced Biosystems·Järvi M Spanjers, Brigitte Städler
Dec 29, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Matheus de Castro LeãoInar Alves Castro
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vasso ApostolopoulosIstvan Toth
Jan 23, 2021·Vaccines·Michael D BuschmannDrew Weissman
Apr 23, 2021·Trends in Pharmacological Sciences·Liudmila L MazaleuskayaGarret A FitzGerald
Dec 29, 2020·Pharmacology & Therapeutics·Nefeli LagopatiVassilis G Gorgoulis
May 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandeep Surendra PanikarPedro Salas
Apr 1, 2021·Annual Review of Biomedical Engineering·Jacob S BrennerVladimir R Muzykantov
Jan 4, 2022·Journal of Biomedical Nanotechnology·Hanmei LiYuxuan Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon saikingaku zasshi. Japanese journal of bacteriology
R Nozawa
Intensive Care Medicine
K L Brigham
Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
E P Shronts
International Ophthalmology Clinics
B A Nichols
© 2022 Meta ULC. All rights reserved