Unintended Effects of GPCR-Targeted Drugs on the Cancer Phenotype.

Trends in Pharmacological Sciences
Abigail C Cornwell, Michael E Feigin

Abstract

G protein-coupled receptors (GPCRs) are the most common class of therapeutic targets, accounting for ~35% of all FDA-approved drugs. Cancer patients receive numerous medications not only to combat cancer but also to alleviate pain, nausea, and anxiety, many of which target GPCRs. Emerging evidence has implicated GPCRs as drivers of cancer progression, therapeutic resistance, and metastasis. Therefore, the effects of commonly prescribed GPCR-targeted drugs must be reevaluated in the context of cancer. Epidemiological and experimental evidence indicate that widely used GPCR-targeted drugs may promote or inhibit cancer progression. It is crucial that we more fully understand the indirect effects of GPCR-targeted drugs on the cancer phenotype. This review summarizes recent advances in characterizing these interactions and highlights future research opportunities.

References

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Balasubramanian, C S Paulose
Oct 23, 2002·The British Journal of Surgery·H J NielsenUNKNOWN Danish RANX05 Colorectal Cancer Study Group
Nov 4, 2004·The Lancet Oncology·Alok A Khorana, Robert L Fine
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ning LiXiaoxin Chen
Apr 8, 2006·Science·Mickael LesurtelPierre-Alain Clavien
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pierre SaviJean-Marc Herbert
Sep 29, 2006·Anesthesiology·Aristomenis K ExadaktylosDaniel I Sessler
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Meike KörnerJean Claude Reubi
Jul 3, 2008·Cancer Research·Antonio NocitoPierre-Alain Clavien
Jan 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher SollPierre-Alain Clavien
Jan 1, 2009·Molecular and Cellular Pharmacology·Elizabeth R RayburnRuiwen Zhang
May 29, 2010·Anesthesiology·Antje GottschalkEdward C Nemergut
Jan 27, 2011·Cancer Metastasis Reviews·Banafsheh AfsharimaniMarie-Odile Parat
Feb 22, 2011·Gastroenterology·Michael ElashoffPeter C Butler
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amal Melhem-BertrandtAna-Maria Gonzalez-Angulo
Jul 21, 2011·Journal of Obesity·Amir H SamMohammad A Ghatei
Feb 18, 2012·The New England Journal of Medicine·Rebecca L StoneAnil K Sood
Sep 12, 2012·Blood·Min Soon ChoVahid Afshar-Kharghan
Jun 26, 2013·British Journal of Anaesthesia·M Al-HashimiD G Lambert
Jul 13, 2013·Science·Claire MagnonPaul S Frenette
Feb 11, 2014·Current Opinion in Cell Biology·Morgan O'HayreJ Silvio Gutkind
Jun 1, 2014·Diabetes·Takashi NomiyamaToshihiko Yanase
Jan 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bani MukhopadhyayGeorge Kunos
Mar 5, 2015·Cell Metabolism·Jacqueline A KoehlerDaniel J Drucker
May 13, 2015·Journal of Biosciences·Miguel MunozMaximino Redondo
Aug 1, 2015·Drug Discovery Today·J Daniel HothersallPhilip Rawlins
Aug 5, 2015·Cancer Research·Gregory N AdamsJoseph S Palumbo
Dec 3, 2015·Gut·Paulina Gomez-RubioUNKNOWN PanGenEU Study Investigators
Mar 19, 2016·Current Opinion in Supportive and Palliative Care·Timothy Wigmore, Paul Farquhar-Smith

❮ Previous
Next ❯

Citations

Aug 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Fan TangXia-Wei Wei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.