Unique age-related transcriptional signature in the nervous system of the long-lived red sea urchin Mesocentrotus franciscanus.

Scientific Reports
Jennifer M PolinskiAndrea Bodnar

Abstract

The red sea urchin, Mesocentrotus franciscanus, is one the earth's longest-lived animals, reported to live more than 100 years with indeterminate growth, life-long reproduction and no increase in mortality rate with age. To gain insight into mechanisms associated with longevity and negligible senescence, age-related transcriptional profiles were examined in tissues of the red sea urchin. Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. There was an age-related upregulation in expression of genes involved in synaptogenesis, axonogenesis and neuroprotection suggesting preservation of neuronal processes with age. There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. This unique age-related gene expression profile in the red sea urchin nervous system may pla...Continue Reading

References

Jun 11, 2004·Nature·Tao LuBruce A Yankner
Dec 22, 2005·Nature Reviews. Genetics·David B AllisonMahyar Sabripour
Jun 2, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Andreas HeylandLeonid L Moroz
Nov 23, 2007·Journal of Applied Physiology·Helen D Kollias, John C McDermott
Nov 28, 2007·Annual Review of Pathology·Bruce A YanknerPatrick Loerch
Feb 5, 2009·Bioinformatics·João Pedro de MagalhãesGeorge M Church
Dec 8, 2009·Trends in Neurosciences·Charles A Hoeffer, Eric Klann
Mar 26, 2010·Nature·Nicholas A BishopBruce A Yankner
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marta M LipinskiJunying Yuan
Sep 8, 2010·Mechanisms of Ageing and Development·Julian C LuiJeffrey Baron
Dec 28, 2010·Mechanisms of Ageing and Development·Masaki Takasugi
Dec 22, 2011·Ageing Research Reviews·Antero Salminen, Kai Kaarniranta
Apr 6, 2012·Mechanisms of Ageing and Development·Jeannette Loram, Andrea Bodnar
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marton Lorant TothMonica Driscoll
Sep 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·João Pedro de Magalhães
Mar 5, 2013·The Journal of Clinical Investigation·Christopher B Newgard, Norman E Sharpless
Jul 31, 2013·Genome Biology·Daniel GlassTim D Spector
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Jan 1, 2014·Genesis : the Journal of Genetics and Development·Rossella AnnunziataMaria I Arnone
Apr 15, 2014·Cell Metabolism·Kristopher BurkewitzWilliam B Mair
Oct 21, 2014·Journal of Neurochemistry·Jill Bouchard, Saul A Villeda
Nov 27, 2014·Frontiers in Molecular Neuroscience·Sandra M Fernandez-MoyaMichael A Kiebler
Dec 17, 2014·Immunological Reviews·Michael J Osborne, Katherine L B Borden
Jan 16, 2015·Cell Cycle·Masahiro MoritaIvan Topisirovic
Mar 12, 2015·G3 : Genes - Genomes - Genetics·Andrew Anand BrownRichard Durbin
Jul 3, 2015·Invertebrate Reproduction & Development·Andrea G Bodnar
Sep 1, 2015·Frontiers in Molecular Neuroscience·Josta T Kevenaar, Casper C Hoogenraad
Mar 8, 2017·The Journal of Biological Chemistry·Haihui Pan, Toren Finkel
Nov 14, 2017·Journal of Chemical Neuroanatomy·Remya ChandranR V Omkumar
Dec 12, 2017·Human Molecular Genetics·Ana ViñuelaKerrin S Small
Jul 15, 2018·Nature Reviews. Molecular Cell Biology·Malene HansenDavid W Walker
Nov 13, 2018·Current Opinion in Toxicology·Carla Garza-LombóRodrigo Franco
Apr 21, 2019·Ageing Research Reviews·María Álvarez-SattaAnder Matheu

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Citations

Sep 17, 2020·Journal of Fish Diseases·Mark P PolinskiKyle A Garver

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Datasets Mentioned

BETA
SRX000089

Methods Mentioned

BETA
RNA-Seq
acetylation
ubiquitination
GTPase
dissection
electrophoresis

Software Mentioned

BUSCO
Sim
IPA
RSEM
BLAST
Primer Express
BLASTP
DESeq 2
Trinity
ENSEMBL

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