Unique alternating peptide-peptoid copolymers from dipeptides via a Ugi reaction in water

Chemical Communications : Chem Comm
A Al SamadA Debuigne

Abstract

Herein, we developed a straightforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via a Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid copolymers as well as block copolymers were produced in a single step in the presence of acrylic acid and carboxylic acid-terminated poly(ethylene glycol). The thermoresponsiveness of these polymers is highlighted.

References

Oct 12, 2000·Angewandte Chemie·A Dömling, I Ugi
Jan 15, 2004·Journal of the American Chemical Society·Michael C Pirrung, Koushik Das Sarma
Apr 8, 2004·Molecular Diversity·Maxim A MironovVladimir S Mokrushin
Apr 5, 2007·Nature Protocols·Stefano Marcaccini, Tomás Torroba
Jun 22, 2011·Macromolecular Rapid Communications·Thomas DefizeMichaël Alexandre
Jun 29, 2011·Angewandte Chemie·Eelco RuijterRomano V A Orru
Mar 2, 2013·Chemical Society Reviews·Debashish RoyBrent S Sumerlin
Jun 1, 2013·ACS Nano·Jing Sun, Ronald N Zuckermann
Dec 5, 2013·Angewandte Chemie·Ryohei Kakuchi
Jan 23, 2014·Chemical Society Reviews·B E I RamakersD W P M Löwik
Sep 23, 2014·Macromolecular Rapid Communications·Ansgar SehlingerMichael A R Meier
Apr 9, 2015·Macromolecular Bioscience·Christian SeckerHelmut Schlaad
Apr 10, 2015·Advanced Materials·Abigail S KnightRonald N Zuckermann
Sep 24, 2015·Macromolecular Rapid Communications·Kristina Klinker, Matthias Barz
Mar 21, 2017·Chemical Communications : Chem Comm·Yasuhito Koyama, Prashant G Gudeangadi

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Citations

Sep 30, 2020·Macromolecular Rapid Communications·Abu Bin IhsanYasuhito Koyama
Oct 7, 2021·Chemical Communications : Chem Comm·Claudine Nicole HerlanStefan Bräse
Sep 26, 2021·Macromolecular Rapid Communications·Botuo ZhengJun Ling

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Methods Mentioned

BETA
NMR

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