Unique and important consequences of RECQ1 deficiency in mammalian cells.

Cell Cycle
Sudha Sharma, R M Brosh

Abstract

Five members of the RecQ subfamily of DEx-H-containing DNA helicases have been identified in both human and mouse, and mutations in BLM, WRN, and RECQ4 are associated with human diseases of premature aging, cancer, and chromosomal instability. Although a genetic disease has not been linked to RECQ1 mutations, RECQ1 helicase is the most highly expressed of the human RecQ helicases, suggesting an important role in cellular DNA metabolism. Recent advances have elucidated a unique role of RECQ1 to suppress genomic instability. Embryonic fibroblasts from RECQ1-deficient mice displayed aneuploidy, chromosomal instability, and increased load of DNA damage.(1) Acute depletion of human RECQ1 renders cells sensitive to DNA damage and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks.(2) Consistent with a role in DNA repair, RECQ1 relocalizes to irradiation-induced nuclear foci and associates with chromatin.(2) RECQ1 catalytic activities(3) and interactions with DNA repair proteins(2,4,5) are likely to be important for its molecular functions in genome homeostasis. Collectively, these studies provide the first evidence for an important role of RECQ1 to confer chromosom...Continue Reading

Citations

Jan 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ashley C W PikeOpher Gileadi
Jan 13, 2010·Molecular and Cellular Biology·Saravanabhavan ThangavelAlessandro Vindigni
Oct 7, 2011·Journal of Nucleic Acids·Sudha Sharma
Nov 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying Qi, Xu Zhou
Mar 13, 2014·Annual Review of Biochemistry·Deborah L CroteauVilhelm A Bohr
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ronald T CottonWilliam E Fisher
Feb 9, 2010·DNA Repair·Natalie C FonvilleSusan M Rosenberg
Mar 17, 2015·The Biochemical Journal·Furqan SamiSudha Sharma
Oct 29, 2010·Cell Cycle·Yuliang Wu, Robert M Brosh
May 1, 2012·DNA Repair·Sudha SharmaJeannine R Larocque
Jan 12, 2010·DNA Repair·Yuliang Wu, Robert M Brosh
Apr 23, 2016·Methods : a Companion to Methods in Enzymology·Xing LuSudha Sharma
Jan 1, 2013·Computational and Structural Biotechnology Journal·Furqan Sami, Sudha Sharma
Mar 3, 2015·Frontiers in Genetics·Fumiaki UchiumiYasuhiro Furuichi
Dec 30, 2014·Frontiers in Genetics·Sudha Sharma
Apr 5, 2017·The EMBO Journal·Jordan WoodrickRabindra Roy
May 21, 2020·Frontiers in Oncology·Martin LiptaySven Rottenberg
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Huiming Lu, Anthony J Davis

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