Unique case of sporadic multiple gastro intestinal stromal tumour

International Journal of Surgery Case Reports
Luigina GraziosiAnnibale Donini

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and they derived from transformed neoplastic precursors of Cajal's interstitial cell (ICC). We are presenting a sporadic and exemplary case of 42 multiple GISTs in a young female patient. Our patient showed anemia for the gastric GIST bleeding and only after other tumors were instrumentally and intra-surgery discovered. The patient showed genetic mutation V559A/1676 T>C of the juxtamembrane domain of the exon 11 causing the replacement of Valine with Alanine in the 559 codon. GISTS estimated annual incidence is 12-14 per million. Multiple GISTs associated with familiarity or hereditary syndromes are described only in few case reports and sporadic mGISTs have not been studied yet. Literature review has been done. We are presenting a sporadic and exemplary case of 42 multiple GISTs in a young female patient localized trough out all the gastrointestinal tract. This is the only case of sporadic multiple GISTs reported in literature.

References

Feb 14, 2007·ANZ Journal of Surgery·Christopher M ByrneMichael Cox
Sep 10, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela GasparottoRoberta Maestro
Feb 27, 2009·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·T B Saleem, I Ahmed
Jun 13, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Guhyun KangKyoung-Mee Kim

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
surgical resection

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.