Unique classification of parathyroid dysfunction in patients with transfusion dependent thalassemia major using Nomogram-A cross sectional study

Annals of Medicine and Surgery
Hafsa MajidA H Khan

Abstract

Hypoparathyroidism is a rare complication of iron overload in patients with transfusion dependent β thalassemia major (β-TM). We aim to determine the prevalence of parathyroid dysfunction in patients with β-TM. Diagnosed cases of transfusion dependent β-TM between 5 and 17 years of age were recruited from outpatient clinics of a non-profit organization in Karachi, Pakistan. Blood and urine samples were collected in fasting to determine Ca, P, Alb, Mg, Cr 25OHD and iPTH. Patients were grouped on the basis of upper and lower levels of Ca, 25OHD and iPTH for assessing parathyroid dysfunction into primary hypoparathyroidism [low calcium (Ca) & intact parathyroid hormone (iPTH)], sub-clinical hypoparathyroidism [low iPTH and 25 hydroxy vitamin D (25OHD), low/normal Ca], normal functioning parathyroid gland [Normal Ca, iPTH and 25OHD] and secondary hyperparathyroidism [high iPTH, low/normal Ca and/or 25OHD]. Using PTH nomogram subject specific expected PTH (maxPTH) was calculated. Difference between maxPTH and measured iPTH was determined to assess the utility of nomogram in identifying parathyroid gland dysfunction. The statistical analysis was performed using the Statistical Package of Social Sciences (SPSS) version 20. Median age ...Continue Reading

References

Feb 6, 2009·The Journal of Clinical Endocrinology and Metabolism·John P BilezikianUNKNOWN Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism
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Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Maria Luisa BrandiJohn T Potts
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Dolores M ShobackRoger Bouillon
Mar 29, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hafsa MajidJamsheer Talati
Sep 1, 2017·Nature Reviews. Disease Primers·Michael MannstadtDolores M Shoback
Sep 12, 2017·International Journal of Surgery·Riaz Ahmed AghaUNKNOWN STROCSS Group
Jun 6, 2018·International Journal of Endocrinology and Metabolism·Ali BaziMojtaba Delaramnasab

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Clinical Trials Mentioned

NCT03947632

Software Mentioned

Statistical Package of Social Sciences ( SPSS )
STROCSS

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