Unique dietary-related mouse model of colitis

Inflammatory Bowel Diseases
Harris BernsteinClaire M Payne

Abstract

A high-fat diet is a risk factor for the development of inflammatory bowel disease (IBD) in humans. Deoxycholate (DOC) is increased in the colonic contents in response to a high-fat diet. Thus, an elevated level of DOC in the colonic lumen may play a role in the natural course of development of IBD. Wild-type B6.129 mice were fed an AIN-93G diet, either supplemented with 0.2% DOC or unsupplemented and sacrificed at 1 week, 1 month, 3 months, 4 months, and 8 months. Colon samples were assessed by histopathological, immunohistochemical, and cDNA microarray analyses. Mice fed the DOC-supplemented diet developed focal areas of colonic inflammation associated with increases in angiogenesis, nitrosative stress, DNA/RNA damage, and proliferation. Genes that play a central role in inflammation and angiogenesis and other related processes such as epithelial barrier function, oxidative stress, apoptosis, cell proliferation/cell cycle/DNA repair, membrane transport, and the ubiquitin-proteasome pathway showed altered expression in the DOC-fed mice compared with the control mice. Changes in expression of individual genes (increases or reductions) correlated over time. These changes were greatest 1 month after the start of DOC feeding. The ...Continue Reading

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Citations

Sep 18, 2010·Inflammatory Bowel Diseases·Qiang GaoFong-Fong Chu
Jan 27, 2011·Archives of Toxicology·Carol BernsteinHarris Bernstein
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Feb 6, 2010·Inflammatory Bowel Diseases·Claire M PayneHarris Bernstein
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Oct 17, 2020·Digestive Diseases and Sciences·Stanislav Sitkin, Juris Pokrotnieks
Mar 31, 2021·Journal of Gastroenterology and Hepatology·Naoki ShibuyaRyota Hokari

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