Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation.

Hypertension
Yang LiuBai-Yan Li

Abstract

This study aims to understand the special expression patterns of angiotensin-II receptor (AT1R and AT2R) in nodose ganglia and nucleus of tractus solitary of baroreflex afferent pathway and their contribution in sex difference of neurocontrol of blood pressure regulation. In this regard, action potentials were recorded in baroreceptor neurons (BRNs) using whole-cell patch techniques; mRNA and protein expression of AT1R and AT2R in nodose ganglia and nucleus of tractus solitary were evaluated using real time-polymerase chain reaction, Western blot, and immunohistochemistry at both tissue and single-cell levels. The in vivo effects of 17β-estradiol on blood pressure and AT2R expression were also tested. The data showed that AT2R, rather than AT1R, expression was higher in female than age-matched male rats. Moreover, AT2R was downregulated in ovariectomized rats, which was restored by the administration of 17β-estradiol. Single-cell real time-polymerase chain reaction data indicated that AT2R was uniquely expressed in Ah-type BRNs. Functional study showed that long-term administration of 17β-estradiol significantly alleviated the blood pressure increase in ovariectomized rats. Electrophysiological recordings showed that angiotensi...Continue Reading

References

May 7, 2002·Journal of Neuroscience Methods·B Y Li, J H Schild
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Thaís Helena MoreiraJader Santos Cruz
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Athar H Siddiqui, Tahir Hussain
Oct 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Bin FengJohn H Schild
Aug 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bai-Yan LiJohn H Schild
Jan 20, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Amanda K StennettRaouf A Khalil
Jul 3, 2009·American Journal of Physiology. Cell Physiology·Guo-Fen QiaoJohn H Schild
Oct 23, 2009·American Journal of Physiology. Cell Physiology·Libin ZhangYu-Long Li
Feb 18, 2011·American Journal of Physiology. Cell Physiology·Bai-Yan LiJohn H Schild
Oct 28, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amanda K SampsonKate M Denton
Jul 17, 2012·Gender Medicine·Christine Maric-Bilkan, Michaele B Manigrasso
Nov 14, 2012·Autonomic Neuroscience : Basic & Clinical·John H Schild, Diana L Kunze
Jun 12, 2013·Clinical Science·Rodrigo Maranon, Jane F Reckelhoff
Aug 2, 2013·International Journal of Biological Sciences·Xiao-Long LuBai-Yan Li
Dec 18, 2013·International Journal of Biological Sciences·Jun-Nan LiBai-Yan Li
Jan 2, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodrigo O MaranonJane F Reckelhoff
May 14, 2014·International Journal of Cardiology·Rong HuoBai-Yan Li
Jul 20, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Grace C Santa Cruz ChavezJohn H Schild

❮ Previous
Next ❯

Citations

May 4, 2017·Hypertension·Katrina M Mirabito Colafella, A H Jan Danser
Mar 26, 2019·Endocrinology·Luis Leon MercadoLaurent Gautron
Jan 22, 2021·CNS Neuroscience & Therapeutics·Jie SunBai-Yan Li
Oct 19, 2019·Brain Research Bulletin·Pei ChenBai-Yan Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.