Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Naoki KabeyaÓscar Monroig

Abstract

Omega-3 (ω3 or n-3) long-chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid and docosahexaenoic acid (DHA), play physiologically important roles in vertebrates. These compounds have long been believed to have originated almost exclusively from aquatic (mostly marine) single-cell organisms. Yet, a recent study has discovered that many invertebrates possess a type of enzymes called methyl-end desaturases (ωx) that enables them to endogenously produce n-3 long-chain PUFA and could make a significant contribution to production of these compounds in the marine environment. Polychaetes are major components of benthic fauna and thus important to maintain a robust food web as a recycler of organic matter and a prey item for higher trophic level species like fish. In the present study, we investigated the ωx enzymes from the common ragworm, Hediste diversicolor, a common inhabitant in sedimentary littoral ecosystems of the North Atlantic. Functional assays of the H. diversicolor ωx demonstrated unique desaturation capacities. An ω3 desaturase mediated the conversion of n-6 fatty acid substrates into their corresponding n-3 products including DHA. A further enzyme possessed unique regioselectivities combining both ...Continue Reading

References

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J P SpychallaJ Browse
Jul 13, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·I El MenyawiW Graninger
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·N HastingsA J Teale
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Suzette L PereiraPradip Mukerji
Oct 10, 2006·IUBMB Life·Antonio D Uttaro
May 19, 2007·The Journal of Biological Chemistry·Dauenpen MeesapyodsukXiao Qiu
Oct 9, 2007·Journal of Lipid Research·Kosuke HashimotoMinoru Kanehisa
Jun 10, 2009·Bioinformatics·Salvador Capella-GutiérrezToni Gabaldón
Dec 19, 2009·Progress in Lipid Research·Hervé GuillouAnders Jacobsson
May 21, 2011·BMC Evolutionary Biology·L Filipe C CastroIsabel Cunha
May 25, 2012·The British Journal of Nutrition·Javier Delgado-ListaFrancisco Perez-Jimenez
Nov 2, 2013·Applied Microbiology and Biotechnology·Mingxuan WangYong Q Chen
Oct 30, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mónica Lopes-MarquesL Filipe C Castro
May 5, 2017·Molecular Biology and Evolution·Vincent LefortOlivier Gascuel
May 12, 2017·Marine Biotechnology·Helu LiuHaibin Zhang
Nov 3, 2017·Frontiers in Plant Science·Aejaz A DarNeelakantan Arumugam
Jan 20, 2018·Annual Review of Food Science and Technology·Fereidoon Shahidi, Priyatharini Ambigaipalan
May 3, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Diego GarridoÓscar Monroig
May 21, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Ralph MenzelLiliane Ruess
Oct 28, 2019·Science·Helen R P PhillipsNico Eisenhauer

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Citations

Jun 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aaron W E Galloway, Suzanne M Budge

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