Unique features of extracellular matrix in the mouse medial nucleus of trapezoid body--implications for physiological functions

Neuroscience
M BlosaMarkus Morawski

Abstract

The medial nucleus of the trapezoid body (MNTB) is a vital structure of sound localization circuits in the auditory brainstem. Each principal cell of MNTB is contacted by a very large presynaptic glutamatergic terminal, the calyx of Held. The MNTB principal cells themselves are surrounded by extracellular matrix components forming prominent perineuronal nets (PNs). Throughout the CNS, PNs, which form lattice-like structures around the somata and proximal dendrites, are associated with distinct types of neurons. PNs are highly enriched in hyaluronan and chondroitin sulfate proteoglycans therefore providing a charged surface structure surrounding the cell body and proximal neurites of these neurons. The localization and composition of PNs have lead investigators to a number of hypotheses about their functions including: creating a specific extracellular ionic milieu around these neurons, stabilizing synapses, and influencing the outgrowth of axons. However, presently the precise functions of PNs are still quite unclear primarily due to the lack of an ideal experimental model system that is highly enriched in PNs and in which the synaptic transmission properties can be precisely measured. The MNTB principal cells could offer such ...Continue Reading

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Citations

Jul 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roger Y Tsien
May 18, 2013·Brain Structure & Function·Eva RáczClara Matesz
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Markus MorawskiMelitta Schachner
May 28, 2015·Developmental Neurobiology·Douglas R KolsonGeorge A Spirou
Jan 13, 2015·Hearing Research·Mandy SonntagMarkus Morawski
Apr 16, 2015·Frontiers in Neuroanatomy·Randy J Kulesza, Benedikt Grothe
Jul 3, 2019·Nature Reviews. Neuroscience·James W FawcettTommaso Pizzorusso
Mar 4, 2014·PloS One·Anna Mari LoneAlan Saghatelian
Mar 3, 2020·Frontiers in Aging Neuroscience·Amir M MafiJeffrey G Mellott
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Feb 20, 2018·Frontiers in Integrative Neuroscience·Shinji MiyataHiroshi Kitagawa
Dec 27, 2017·The Journal of Comparative Neurology·Nichole L Beebe, Brett R Schofield
Aug 2, 2020·The European Journal of Neuroscience·Sophie SchmidtMarkus Morawski
Aug 21, 2021·Cellular & Molecular Immunology·Joshua D CrapserKim N Green

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