Unique genetic signatures of local adaptation over space and time for diapause, an ecologically relevant complex trait, in Drosophila melanogaster.

PLoS Genetics
Priscilla A EricksonAlan O Bergland

Abstract

Organisms living in seasonally variable environments utilize cues such as light and temperature to induce plastic responses, enabling them to exploit favorable seasons and avoid unfavorable ones. Local adapation can result in variation in seasonal responses, but the genetic basis and evolutionary history of this variation remains elusive. Many insects, including Drosophila melanogaster, are able to undergo an arrest of reproductive development (diapause) in response to unfavorable conditions. In D. melanogaster, the ability to diapause is more common in high latitude populations, where flies endure harsher winters, and in the spring, reflecting differential survivorship of overwintering populations. Using a novel hybrid swarm-based genome wide association study, we examined the genetic basis and evolutionary history of ovarian diapause. We exposed outbred females to different temperatures and day lengths, characterized ovarian development for over 2800 flies, and reconstructed their complete, phased genomes. We found that diapause, scored at two different developmental cutoffs, has modest heritability, and we identified hundreds of SNPs associated with each of the two phenotypes. Alleles associated with one of the diapause phen...Continue Reading

References

Jan 1, 1992·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·T OhtsuS H Hori
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S SaundersL I Gilbert
Apr 7, 1999·Developmental Biology·M SollerE Kubli
Feb 22, 2001·Developmental Biology·D Drummond-Barbosa, A C Spradling
Dec 1, 2001·Annual Review of Entomology·David L Denlinger
Dec 21, 2002·Evolution & Development·H Frederik Nijhout
May 29, 2003·Journal of Insect Physiology·L I. GilbertD S. Richard
Sep 10, 2004·Developmental Biology·Kimberly McCall
Aug 13, 2005·Bioinformatics·Tobias SingThomas Lengauer
Dec 8, 2005·Journal of Insect Physiology·Vladimír Kostál
Feb 24, 2006·PLoS Biology·Benjamin F VoightJonathan K Pritchard
Jun 14, 2006·BMC Biology·C Adam MiddletonChristopher J H Elliott
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karen D WilliamsMarla B Sokolowski
Jun 30, 2007·Science·Federica SandrelliCharalambos P Kyriacou
Aug 10, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew J PaulWilliam J Schwartz
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kwang Pum LeeDavid Raubenheimer
May 31, 2008·Journal of Insect Physiology·N E Gruntenko, I Yu Rauschenbach
Aug 19, 2008·The American Naturalist·M TatarN K Priest
Oct 7, 2008·The Journal of Heredity·Bing Han, David L Denlinger
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paul S SchmidtWalter F Eanes
Jan 30, 2009·Bioinformatics·Tong Tong WuKenneth Lange
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 3, 2009·Journal of Biomedical Science·Hsing-Hsi LiGwo-Jen Liaw
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Aug 12, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Kevin J EmersonChristina M Holzapfel
Mar 2, 2010·The Journal of Experimental Biology·J S Bale, S A L Hayward
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Feb 10, 2012·Nature·Trudy F C MackayRichard A Gibbs
Jun 7, 2012·Nature Methods·Jennifer ListgartenDavid Heckerman
Aug 18, 2012·Nature Reviews. Genetics·Fernando Andrés, George Coupland
Oct 17, 2012·PLoS Genetics·Josep M ComeronSamuel Bailin
Jan 30, 2013·Evolution; International Journal of Organic Evolution·William PitchersIan Dworkin
Feb 1, 2013·Molecular Biology and Evolution·Darren KessnerJohn Novembre

❮ Previous
Next ❯

Citations

Mar 8, 2021·G3 : Genes - Genomes - Genetics·Cory A WellerAlan O Bergland
Jul 31, 2021·Frontiers in Genetics·Murillo F Rodrigues, Rodrigo Cogni
Sep 2, 2021·Molecular Biology and Evolution·Martin KapunAlan O Bergland
Nov 9, 2021·G3 : Genes - Genomes - Genetics·Timothy J S RamnarineJohn Parsch

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA383555

Methods Mentioned

BETA
genotyping
dissect
two hybrid
dissection

Software Mentioned

Timema
ggplot2
R packages
GATK
PEAR
R
Unified Genotyper
bwa
ROCR
RABBIT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
A V Makrushin
L' Année biologique
I AGRELL
Annual Review of Entomology
David L Denlinger, Peter A Armbruster
© 2021 Meta ULC. All rights reserved