Unique geospatial accumulations of uveal melanoma

American Journal of Ophthalmology
Marlana OrloffTakami Sato

Abstract

Uveal melanoma (UM) is the most common primary malignant eye tumor in adults, though rare with 2500 cases diagnosed annually in the US. Despite a growing understanding of the molecular characteristics, there remains uncertainty regarding epidemiologic trends and environmental risk factors. We have identified three geographic accumulations of UM: 1) Huntersville, NC, 2) Auburn, AL, and 3) Broome/Tioga Counties, NY. Evaluation into these groups will guide ongoing efforts to discover potential risk factors and assist with future treatment and prevention. Observational case series METHODS: Descriptive data from medical records, patient interviews, and questionnaires was obtained on 5 patients from NC, 6 from AL, and 14 from NY. Standard incidence ratio (SIR) calculations were provided by the respective states' cancer registries. In NC, 5 females who were identified as living in Huntersville, NC were diagnosed with UM at ages 20, 22, 24, 30, and 31. The SIR calculations considering the observed and expected incidence was 0.7 (95% CI 0.5-0.9) in Mecklenberg County. In AL, 6 individuals who were identified as either attending Auburn University or employed there during 1989-1993 were diagnosed with UM. Initial SIR calculations for whit...Continue Reading

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