Unique maternal immune and functional microbial profiles during prenatal stress.

Scientific Reports
A. M. AntonsonTamar L Gur

Abstract

Maternal stress during pregnancy is widespread and is associated with poor offspring outcomes, including long-term mental health issues. Prenatal stress-induced fetal neuroinflammation is thought to underlie aberrant neurodevelopment and to derive from a disruption in intrauterine immune homeostasis, though the exact origins are incompletely defined. We aimed to identify divergent immune and microbial metagenome profiles of stressed gestating mice that may trigger detrimental inflammatory signaling at the maternal-fetal interface. In response to stress, maternal glucocorticoid circuit activation corresponded with indicators of systemic immunosuppression. At the maternal-fetal interface, density of placental mononuclear leukocytes decreased with stress, yet maternal whole blood leukocyte analysis indicated monocytosis and classical M1 phenotypic shifts. Genome-resolved microbial metagenomic analyses revealed reductions in genes, microbial strains, and metabolic pathways in stressed dams that are primarily associated with pro-inflammatory function. In particular, disrupted Parasutterella excrementihominis appears to be integral to inflammatory and metabolic dysregulation during prenatal stress. Overall, these perturbations in mat...Continue Reading

References

Dec 1, 1982·Journal of Steroid Biochemistry·J WinterV D Bokkenheuser
May 8, 1999·The American Journal of Clinical Nutrition·R I MackieH R Gaskins
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Apr 16, 2004·Journal of Pediatric Gastroenterology and Nutrition·Michael T BaileyChristopher L Coe
Nov 16, 2004·Trends in Endocrinology and Metabolism : TEM·Michal A Elovitz, Conjeevaram Mrinalini
Apr 19, 2005·Journal of Neuroimmunology·Volker StefanskiMarcus Schulte
Jul 13, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M Sean EsplinEli Y Adashi
Jul 28, 2005·Psychosomatic Medicine·Mary E Coussons-ReadScott Giese
Jul 11, 2006·Physiology & Behavior·Bridget R Mueller, Tracy L Bale
Oct 13, 2006·Brain, Behavior, and Immunity·Mary E Coussons-ReadChristopher D Nettles
Sep 25, 2007·Brain, Behavior, and Immunity·Stephanie L BowersRandy J Nelson
Jul 2, 2008·The International Journal of Neuroscience·Tiffany Field, Miguel Diego
Jul 19, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aaron A TeitelbaumMary H Perdue
Sep 30, 2008·Nature Immunology·Tina RubicJosé M Carballido
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Apr 7, 2010·American Journal of Reproductive Immunology : AJRI·Gil Mor, Ingrid Cardenas
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight
Jul 2, 2010·Hormones and Behavior·Anjanette Harris, Jonathan Seckl
Sep 25, 2010·Nature·Sebastian E WinterAndreas J Bäumler
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John T HunzekerChristopher C Norbury
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Feb 3, 2012·Nature·Jorge Henao-MejiaRichard A Flavell
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·M L TurnerI M Sheldon
Jan 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J GosalbesM P Francino
Mar 29, 2013·Nature·G M TannahillL A J O'Neill
Sep 3, 2013·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Surabhi ChandraArvind Kumar Vaish
Apr 9, 2014·Early Human Development·Arsenio SpinilloBarbara Gardella
May 31, 2014·European Child & Adolescent Psychiatry·Roseriet BeijersCarolina de Weerth
Jun 24, 2014·Nature Medicine·Timo HeidtMatthias Nahrendorf
Jun 24, 2014·American Journal of Obstetrics and Gynecology·Lisa M Christian
Aug 16, 2014·Science·Roberto RomeroSusan J Fisher
Sep 15, 2014·Nature Methods·Johannes AlnebergChristopher Quince
Sep 23, 2014·Stress : the International Journal on the Biology of Stress·Guanhui LiuYaoxing Chen
Sep 23, 2014·American Journal of Reproductive Immunology : AJRI·Bruna de Andrade RamosSteven S Witkin
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

❮ Previous
Next ❯

Citations

Jun 3, 2021·Animals : an Open Access Journal From MDPI·Sha JiangHeng-Wei Cheng
Jul 20, 2021·Behavioural Brain Research·Jeffrey D GalleyTamar L Gur

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
cesarean section
Protein Assay
ELISAs
ELISA
Assay
FACS

Software Mentioned

MetaBAT2
HUMAnN
Prodigal
KEGGDecoder
MEGAHIT
metaWRAP
MetaPhlAn2
FlowJo
LEfSe
metaQUAST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.