Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis

Translational Research : the Journal of Laboratory and Clinical Medicine
Ayse L MindikogluCristian Coarfa

Abstract

The application of nontargeted metabolomic profiling has recently become a powerful noninvasive tool to discover new clinical biomarkers. This study aimed to identify metabolic pathways that could be exploited for prognostic and therapeutic purposes in hepatorenal dysfunction in cirrhosis. One hundred three subjects with cirrhosis had glomerular filtration rate (GFR) measured using iothalamate plasma clearance, and were followed until death, transplantation, or the last encounter. Concomitantly, plasma metabolomic profiling was performed using ultrahigh performance liquid chromatography-tandem mass spectrometry to identify preliminary metabolomic biomarker candidates. Among the 1028 metabolites identified, 34 were significantly increased in subjects with high liver and kidney disease severity compared with those with low liver and kidney disease severity. The highest average fold-change (2.39) was for 4-acetamidobutanoate. Metabolite-based enriched pathways were significantly associated with the identified metabolomic signature (P values ranged from 2.07E-06 to 0.02919). Ascorbate and aldarate metabolism, methylation, and glucuronidation were among the most significant protein-based enriched pathways associated with this metabo...Continue Reading

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Citations

Sep 29, 2019·PloS One·Jasmohan S BajajOliver Fiehn
Oct 27, 2018·Metabolites·Vinshi KhanAyse L Mindikoglu
May 19, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong
Jun 11, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong

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