PMID: 9539766May 16, 1998Paper

Unique molecular surface features of in vivo tolerized T cells

Proceedings of the National Academy of Sciences of the United States of America
C C MaierM I Greene

Abstract

Differential expression of surface markers can frequently be used to distinguish functional subsets of T cells, yet a surface phenotype unique to T cells induced into an anergic state has not been described. Here, we report that CD4 T cells rendered anergic in vivo by superantigen can be identified by loss of the 6C10 T cell marker. Inoculation of Vbeta8.1 T cell antigen receptor (TCR) transgenic mice with a Vbeta8.1-reactive minor lymphocyte-stimulating superantigen (Mls-1(a)) induces tolerance to Mls-1(a) by clonal anergy. CD4 lymph node T cells from Mls-1(a) inoculated transgenic mice enriched for the 6C10(-) phenotype neither proliferate nor produce interleukin-2 upon TCR engagement, whereas 6C10(+) CD4 T cells retain responsiveness. Analysis of T cell memory markers demonstrate that 6C10(-) T cells remain 3G11(hi) but express heterogeneous levels of CD45RB, CD62L, CD44, and the CD69 early activation marker, suggesting that T cells at various degrees of activation can be functionally anergic. These studies demonstrate that anergic T cells can be purified based on 6C10 expression permitting examination of issues concerning biochemical and biological features specific to T cell anergy.

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Citations

Nov 25, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M R Hilleman
Nov 19, 2010·International Immunopharmacology·Fang ZhouAbdolmohamad Rostami
Jul 14, 2010·Journal of the Neurological Sciences·Zhao ZhaoAbdolmohamad Rostami
Aug 15, 2006·Immunological Reviews·Bin LiMark I Greene
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guang-Xian ZhangAbdolmohamad Rostami
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christophe Viret, Charles A Janeway
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire L AdamsPaul Garside
Nov 18, 2005·International Immunology·Patrick J BrennanMark I Greene

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