Unique precursors for the mesenchymal cells involved in injury response and fibrosis.

Proceedings of the National Academy of Sciences of the United States of America
Janice L WalkerA Sue Menko

Abstract

We investigated an alternative pathway for emergence of the mesenchymal cells involved in epithelial sheet wound healing and a source of myofibroblasts that cause fibrosis. Using a mock cataract surgery model, we discovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among lens epithelial cells that expressed the surface antigen G8 and mRNA for the myogenic transcription factor MyoD. These cells rapidly responded to wounding of the lens epithelium with population expansion, acquisition of a mesenchymal phenotype, and migration to the wound edges where they regulate the wound response of the epithelium. These mesenchymal cells also were a principal source of myofibroblasts that emerged following lens injury and were responsible for fibrotic disease of the lens that occurs following cataract surgery. These studies provide insight into the mechanisms of wound-healing and fibrosis.

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Citations

Feb 2, 2013·Clinical and Translational Medicine·Ilknur OzenGesine Paul
Dec 7, 2013·Biochemical Pharmacology·Ellen SchmuhlBurkhard Hinz
Jan 31, 2014·Molecular Biology of the Cell·A S MenkoJ L Walker
Dec 15, 2015·Molecular Biology of the Cell·Brigid M BleakenJanice L Walker
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Nov 28, 2017·Scientific Reports·Caitlin M LoganA Sue Menko
Feb 16, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·A Sue MenkoMary Ann Stepp
May 25, 2012·Experimental Dermatology·Jacquelyn GerhartMindy George-Weinstein
Jan 18, 2017·The Journal of Pharmacology and Experimental Therapeutics·Jacquelyn GerhartMindy George-Weinstein
Jul 3, 2020·PloS One·Jacquelyn GerhartMindy George-Weinstein
Aug 25, 2020·PloS One·Jacquelyn GerhartMindy George-Weinstein
May 3, 2019·Investigative Ophthalmology & Visual Science·Jacquelyn GerhartMindy George-Weinstein
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Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Sue MenkoJanice L Walker
Sep 26, 2020·Progress in Retinal and Eye Research·I M WormstoneJ A Eldred
Jun 15, 2021·Experimental Eye Research·Janice L Walker, A Sue Menko

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