Unique roles of infiltrating myeloid cells in the murine uterus during early to midpregnancy

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hui ZhaoDavid K Stevenson

Abstract

Leukocyte infiltration into the uterus is a characteristic feature in early to midpregnancy, but the composition and function of these leukocytes are not well understood. Using a pregnant murine model, we showed that myeloid cells and uterine NK (uNK) cells were the predominant populations in uteri during early to midgestation, whereas T and B cells were constrained. Uterine myeloid populations included cells that infiltrated from the circulation (myeloid-derived suppressor cells [MDSCs], monocyte-derived macrophages [Mφs], and dendritic cells [DCs]) or proliferated from resident precursors (resident Mφs [Re-Mφs] and DCs). CD11b(hi)Ly6-G(hi) cells, representing neutrophils in both blood and uterine MDSCs, significantly increased from embryonic days 8.5 to 9.5. To understand their putative functions, we used anti-Gr-1 Ab to deplete circulating neutrophils and uterine MDSCs. In the absence of MDSC suppression, uterine DCs, T cells, and regulatory T cells expanded. Conversely, uterine MDSCs responded to LPS-induced inflammation and transformed into CD14(+)-activated neutrophils, resulting in an upregulation of tolerogenic DCs. A high dose of LPS (2.5 μg/mouse) significantly increased the influx of neutrophils and production of pro...Continue Reading

References

Nov 1, 1984·The Journal of Experimental Medicine·R van Furth, M M Diesselhoff-den Dulk
Jun 3, 2000·Annual Review of Immunology·A L Mellor, D H Munn
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Jul 16, 2005·Blood·Julien Y BertrandIsabelle Godin
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaun P MurphySurendra Sharma
Jul 27, 2006·Nature Reviews. Immunology·Ashley Moffett, Charlie Loke
Nov 15, 2006·Immunological Reviews·B Anne CroyChandrakant Tayade
Jan 5, 2007·Annual Review of Immunology·Ana Cumano, Isabelle Godin
Nov 21, 2007·Nature Medicine·Sandra M BloisPetra C Arck
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Jul 17, 2008·International Immunology·Hagai AmsalemJacob Rachmilewitz
Aug 22, 2008·Immunological Investigations·Caroline DunkRebecca Lee Jones
Aug 22, 2008·Immunological Investigations·Kristina M Adams Waldorf, J Lee Nelson
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Je-In YounDmitry I Gabrilovich
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hakim YadiFrancesco Colucci
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brenda C TimmonsMala S Mahendroo
Mar 17, 2009·Science·Kang LiuMichel Nussenzweig
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica E ThaxtonSurendra Sharma
Jul 29, 2009·European Journal of Immunology·Verena GreifenbergManfred B Lutz
Oct 31, 2009·The International Journal of Developmental Biology·Judith N BulmerGendie E Lash
Jan 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandy L HouserJack L Strominger
Mar 23, 2011·American Journal of Obstetrics and Gynecology·Ofer FainaruMordechai Hallak
Apr 15, 2011·Immunological Reviews·Alba Munoz-SuanoAlexander G Betz
Jun 8, 2011·The Journal of Clinical Investigation·Laetitia A MautiIvan Stamenkovic
Aug 10, 2011·The Journal of Experimental Medicine·Elisa TaglianiAdrian Erlebacher
Sep 8, 2011·Expert Review of Clinical Immunology·Elisa Tagliani, Adrian Erlebacher
Mar 24, 2012·Science·Christian SchulzFrederic Geissmann
Oct 31, 2012·Journal of Leukocyte Biology·Uma ThiruchelvamHilary O D Critchley
Dec 15, 2012·Nature Reviews. Immunology·Adrian Erlebacher
Dec 20, 2012·Journal of Leukocyte Biology·Steffen SchusterFabienne Tacchini-Cottier
Feb 6, 2013·Journal of Cellular and Molecular Medicine·Oksana ShynlovaStephen J Lye
Feb 21, 2013·Cellular and Molecular Life Sciences : CMLS·Janesh PillayLeo Koenderman

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Citations

Jan 10, 2018·Biology of Reproduction·Svetlana DambaevaKenneth D Beaman
Jun 12, 2016·Seminars in Immunopathology·Mayumi MoriJúlia Szekeres-Bartho
Nov 2, 2018·The Journal of Clinical Investigation·Markus AbelnBirgit Weinhold
Jul 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott M GordonEdward M Behrens
Dec 30, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natascha KöstlinChristian Gille
Feb 4, 2016·American Journal of Reproductive Immunology : AJRI·Catharina BartmannUlrike Kämmerer
Jul 21, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Brice GaudillièreMartin S Angst
Feb 16, 2017·American Journal of Hypertension·Catalina A Lopez Gelston, Brett M Mitchell
Nov 10, 2020·Frontiers in Immunology·Natascha Köstlin-Gille, Christian Gille
Jun 9, 2021·Reproductive Sciences·Dan LiYeling Wang

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