PMID: 15332440Aug 31, 2004Paper

Unique self-sustaining circadian oscillators within the brain of Drosophila melanogaster

Chronobiology International
Shobi Veleri, Corinna Wülbeck

Abstract

In Drosophila circadian rhythms persist in constant darkness (DD). The small ventral Lateral Neurons (s-LNv) mainly control the behavioral circadian rhythm in consortium with the large ventral Lateral Neurons (l-LNv) and dorsal Lateral Neurons (LNd). It is believed that the molecular oscillations of clock genes are the source of this persistent behavior. Indeed the s-LNv, LNd, Dorsal Neurons (DN)-DN2 and DN3 displayed self-sustained molecular oscillations in DD both at RNA and protein levels, except the DN2 oscillates in anti-phase. In contrast, the l-LNv and DN1 displayed self-sustained oscillations at the RNA level, but protein oscillations quickly dampened. Having self-sustained and dampened molecular oscillators together in the DN groups suggested that they play different roles. However, all DN groups seemed to contribute together to the light-dark (LD) behavioral rhythm. The LD entrainment of LN oscillators is achieved through Rhodopsin (RH) and Cryptochrome (CRY). CRY's expression in all DN groups implicates also its role in LD entrainment of DN, like in DN1. However, mutations in cry and glass that did not inflict LD synchronization of the DN2, DN3 oscillator implicate the existence of a novel photoreceptor at least in DN3.

References

Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Jan 1, 1981·Molecular & General Genetics : MGG·R F Smith, R J Konopka
Apr 8, 1998·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·C Helfrich-Förster
Aug 11, 1998·Neuron·S M Reppert
Jun 6, 2000·Neuron·P EmeryM Rosbash
Oct 4, 2000·Physiological Genomics·I Edery
Jul 12, 2002·Cell and Tissue Research·Ralf Stanewsky
Dec 18, 2002·Journal of Neurobiology·Ralf Stanewsky
Sep 11, 2003·Microscopy Research and Technique·Charlotte Helfrich-Förster
Sep 17, 2003·PLoS Biology·Ying PengMichael Rosbash
Oct 17, 2003·Current Biology : CB·Shobi VeleriRalf Stanewsky
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·André KlarsfeldFrançois Rouyer
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·Charlotte Helfrich-Förster

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Citations

Sep 17, 2008·Essays in Biochemistry·Dhanya MullasseryMichael R H White
Dec 7, 2007·Brain Research Reviews·Mariska J VansteenselJohanna H Meijer

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