Unique sequence features of the Human adenovirus 31 complete genomic sequence are conserved in clinical isolates.

BMC Genomics
Soeren HofmayerAlbert Heim

Abstract

Human adenoviruses (HAdV) are causing a broad spectrum of diseases. One of the most severe forms of adenovirus infection is a disseminated disease resulting in significant morbidity and mortality. Several reports in recent years have identified HAdV-31 from species A (HAdV-A31) as a cause of disseminated disease in children following haematopoetic stem cell transplantation (hSCT) and liver transplantation. We sequenced and analyzed the complete genome of the HAdV-A31 prototype strain to uncover unique sequence motifs associated with its high virulence. Moreover, we sequenced coding regions known to be essential for tropism and virulence (early transcription units E1A, E3, E4, the fiber knob and the penton base) of HAdV-A31 clinical isolates from patients with disseminated disease. The genome size of HAdV-A31 is 33763 base pairs (bp) in length with a GC content of 46.36%. Nucleotide alignment to the closely related HAdV-A12 revealed an overall homology of 84.2%. The genome organization into early, intermediate and late regions is similar to HAdV-A12. Sequence analysis of the prototype strain showed unique sequence features such as an immunoglobulin-like domain in the species A specific gene product E3 CR1 beta and a potentially ...Continue Reading

References

Feb 1, 1991·The Journal of Infectious Diseases·M E JohanssonG Wadell
May 24, 1991·Science·A LupasJ Stock
Jul 1, 1984·Clinical Pediatrics·A M BhatF Yehia
Oct 1, 1994·Journal of Virology·P MathiasG Nemerow
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·J V GeisbergR P Ricciardi
Mar 13, 1999·Journal of Clinical Microbiology·L K Crawford-MikszaD P Schnurr
Mar 20, 1999·Bone Marrow Transplantation·G A HaleC C Patrick
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A DakhamaY Cormier
Jul 10, 1999·Immunological Reviews·J A Mahr, L R Gooding
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N K ChatterjeeT M Church
Dec 26, 2001·Nucleic Acids Research·Alex BatemanErik L L Sonnhammer
Apr 3, 2002·Emerging Infectious Diseases·Dean D ErdmanLarry J Anderson
Jul 23, 2002·Journal of Virology·Nikita AvvakumovJoe S Mymryk
Feb 1, 2003·The Lancet Infectious Diseases·Tony WallsDelane Shingadia
Mar 26, 2003·Genome Research·Michael BrudnoSerafim Batzoglou
Jun 26, 2003·Nucleic Acids Research·Karsten HillerRichard Münch
Oct 24, 2003·The Journal of General Virology·Andrew J DavisonBalázs Harrach
Dec 19, 2003·Nucleic Acids Research·Nicolas HuloAmos Bairoch
Feb 24, 2004·The Journal of Gene Medicine·Marshall S Horwitz
Dec 4, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kathrin SeidemannArmin Wessel
Jan 28, 2006·Journal of Virology·T SubramanianG Chinnadurai
May 16, 2006·Bone Marrow Transplantation·M Leruez-VilleS Blanche

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Citations

Sep 2, 2011·The Journal of General Virology·Yuki MatsushimaHiroshi Ushijima
Jun 15, 2010·Virology·Michael P WalshMorris S Jones
Apr 1, 2016·The Journal of General Virology·Bing TanZheng-Li Shi
May 28, 2019·Expert Review of Vaccines·Franck J D MennechetEric J Kremer
Aug 23, 2019·Biomedicines·Brennetta J CrenshawQiana L Matthews
Sep 27, 2018·Frontiers in Microbiology·Ashrafali M IsmailJaya Rajaiya
Nov 27, 2019·FEBS Letters·Ashrafali Mohamed IsmailJames Chodosh
Apr 29, 2019·The Science of the Total Environment·Jennifer H LunPeter A White

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Datasets Mentioned

BETA
AM749299
U14653
AF534906
DQ086466
AY599837
AB448768
AJ854486
AY601636

Methods Mentioned

BETA
glycosylation
PCR
electrophoresis

Software Mentioned

ProSite
mVISTA Limited Global Alignment of ( LAGAN )
BLAST
BioEdit
JVirGel
COILS
LAGAN
BLASTp
MEGA
SeqMan

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