Unique sex determination system in the silkworm, Bombyx mori: current status and beyond

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Susumu KatsumaKen Sahara

Abstract

The silkworm Bombyx mori has been used for silk production for over 5,000 years. In addition to its contribution to sericulture, B. mori has played an important role in the field of genetics. Classical genetic studies revealed that a gene(s) with a strong feminizing activity is located on the W chromosome, but this W-linked feminizing gene, called Feminizer (Fem), had not been cloned despite more than 80 years of study. In 2014, we discovered that Fem is a precursor of a single W chromosome-derived PIWI-interacting RNA (piRNA). Fem-derived piRNA binds to PIWI protein, and this complex then cleaves the mRNA of the Z-linked Masculinizer (Masc) gene, which encodes a protein required for both masculinization and dosage compensation. These findings showed that the piRNA-mediated interaction between the two sex chromosomes is the primary signal for the sex determination cascade in B. mori. In this review, we summarize the history, current status, and perspective of studies on sex determination and related topics in B. mori.

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Citations

Jul 12, 2019·FEBS Open Bio·Susumu KatsumaTakashi Kiuchi
Aug 28, 2021·International Journal of Molecular Sciences·Zhongyuan DengXianchun Li
Nov 23, 2021·Journal of Tissue Engineering and Regenerative Medicine·Mohammad Hossein KhosropanahMasoumeh Majidi Zolbin

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Methods Mentioned

BETA
PCR
transfection
transgenic
RNA-seq

Software Mentioned

BLAST
Feminizer

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