Unique signatures of natural background radiation on human Y chromosomes from Kerala, India

PloS One
Sanjay PremiSher Ali

Abstract

The most frequently observed major consequences of ionizing radiation are chromosomal lesions and cancers, although the entire genome may be affected. Owing to its haploid status and absence of recombination, the human Y chromosome is an ideal candidate to be assessed for possible genetic alterations induced by ionizing radiation. We studied the human Y chromosome in 390 males from the South Indian state of Kerala, where the level of natural background radiation (NBR) is ten-fold higher than the worldwide average, and that from 790 unexposed males as control. We observed random microdeletions in the Azoospermia factor (AZF) a, b and c regions in >90%, and tandem duplication and copy number polymorphism (CNP) of 11 different Y-linked genes in about 80% of males exposed to NBR. The autosomal homologues of Y-linked CDY genes largely remained unaffected. Multiple polymorphic copies of the Y-linked genes showing single Y-specific signals suggested their tandem duplication. Some exposed males showed unilocus duplication of DAZ genes resulting in six copies. Notably, in the AZFa region, approximately 25% of exposed males showed deletion of the DBY gene, whereas flanking genes USP9Y and UTY remained unaffected. All these alterations we...Continue Reading

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Citations

Mar 23, 2010·Human Reproduction Update·Paulo Navarro-CostaCarlos E Plancha
Aug 10, 2010·BMC Medical Genomics·Safdar Ali, Sher Ali
Nov 10, 2012·Biological Reviews of the Cambridge Philosophical Society·Anders P Møller, Timothy A Mousseau
Jun 4, 2010·Radiation Research·John D BoiceKazuo Yoshida
Nov 21, 2017·Evolutionary Applications·Robert J BakerCaleb D Phillips
Apr 8, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sanjay PremiSher Ali
Oct 13, 2019·Environmental and Molecular Mutagenesis·Maria Grazia AndreassiEugenio Picano

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Methods Mentioned

BETA
PCR
PCRs
Fluorescence
chromosomal aberrations
Assay

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