Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice

Immunological Reviews
B A JacobsonA Marshak-Rothstein

Abstract

MRL/lpr (Fas-deficient) mice develop an autoimmune syndrome associated with excessive production of autoantibodies. A significant portion of these autoantibodies are IgG2a molecules specific for many of the autoantigens recognized by the sera of patients with systemic lupus erythematosus. In addition, MRL/lpr mice make exceedingly high titers of IgG or IgA rheumatoid factors (RF) specific for autologous IgG2a. The microenvironment of the IgG2a-producing B cells as well as the prototypic RF autoantibodies was determined by a combination of immunohistochemical and in situ hybridization techniques. In contrast to the antibody-producing cells present in mice responding to conventional foreign antigens, both IgG2a+ and RF+ B cells were found to be densely clustered in the T-cell-rich inner periarteriolar lymphatic sheath of the spleen. These results suggest that conventional antibody and autoantibody production in MRL/lpr mice may be mechanistically distinct processes.

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Feb 1, 1991·The Journal of Experimental Medicine·E Roosnek, A Lanzavecchia
Apr 1, 1990·The American Journal of Anatomy·T C Pellas, L Weiss
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L ReiningerS Izui
Mar 1, 1988·Clinical Immunology and Immunopathology·C B WolfowiczA Marshak-Rothstein
Aug 2, 1987·Nature·M J ShlomchikM G Weigert
Jan 1, 1981·Immunological Reviews·A N Theofilopoulos, F J Dixon
Nov 1, 1995·European Journal of Immunology·L MandikJ Erikson
Sep 1, 1995·Clinical Immunology and Immunopathology·R J Noelle
Nov 1, 1995·The Journal of Experimental Medicine·P GarroneJ Banchereau
Jul 1, 1995·British Journal of Rheumatology·G FauldsD Latchman
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Jun 1, 1993·International Immunology·C KlasP H Krammer
Jan 19, 1995·Nature·C ChenM Weigert
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H RussellR Wang
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·K G SmithD M Tarlinton
Apr 1, 1996·The Journal of Experimental Medicine·D A CroixM C Carroll
Oct 1, 1996·The Journal of Experimental Medicine·Y J Liu, J Banchereau
Jan 1, 1979·Perspectives in Biology and Medicine·R M Chanock, B R Murphy

❮ Previous
Next ❯

Citations

Feb 28, 1998·Immunologic Research·J EriksonJ H Roark
Feb 11, 2003·Cellular Immunology·Nobuhiko KayagakiHideo Yagita
May 14, 1999·Immunology Today·S E TownsendC C Goodnow
Jun 8, 2004·Arthritis Research & Therapy·Amrie C Grammer, Peter E Lipsky
Nov 26, 2009·Nature Reviews. Immunology·Carola G VinuesaMatthew C Cook
Mar 17, 2006·European Journal of Immunology·Christopher M ReillyGary S Gilkeson
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele L FieldsJan Erikson
Dec 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony ChangMarcus R Clark
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adriana del ReyHugo O Besedovsky
Nov 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinya TanakaChen Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.