Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury

Journal of Neurotrauma
Prithvi K ShahYury Gerasimenko

Abstract

Spinal cord epidural stimulation has resulted in the initiation of voluntary leg movements and improvement in postural, bladder, and sexual function. However, one of the limitations in reaching the full potential of epidural stimulation for therapeutic purposes in humans has been the identification of optimal stimulation configurations that can neuromodulate the spinal cord for stepping. In the present work, we investigated the mechanisms underlying the specificity of interaction between the rostral and caudal spinal cord circuitries in enabling locomotion in spinal rats (n = 10) by epidural spinal cord stimulation. By using unique spatiotemporal epidural stimulation parameters of the lumbar and sacral spinal cords, a robust stepping pattern in spinal rats was observed with only six training sessions and as early as 3 weeks post-injury. Electrophysiological evidence reveals that in addition to frequency of stimulation pulses at the stimulation sites, the relative timing between stimulation pulses applied at the lumbar (L2) and sacral (S1) segments of the spinal cord heavily impacted stepping performance. Best stepping was established at a higher stimulation frequency (40 Hz vs. 5, 10, 15, and 20Hz) and at specific relative time...Continue Reading

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Citations

Mar 28, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Prithvi K Shah, Igor Lavrov
Aug 18, 2017·Physiology·Aiva Ievins, Chet T Moritz
Apr 14, 2018·Journal of Neurotrauma·Parag GadV Reggie Edgerton
Oct 27, 2018·Journal of Neurotrauma·Dimitry G SayenkoYury P Gerasimenko
Apr 4, 2019·Journal of Neurophysiology·Yury GerasimenkoPrithvi K Shah
Nov 7, 2019·Neurorehabilitation and Neural Repair·Hui ZhongV Reggie Edgerton
Dec 21, 2019·Neurorehabilitation and Neural Repair·Alvaro Megía GarcíaJulio Gómez-Soriano
Feb 16, 2017·Neural Regeneration Research·Prithvi K Shah, Yury Gerasimenko
Oct 28, 2017·Frontiers in Neuroanatomy·Carlos A CuellarIgor A Lavrov
Oct 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Petr KrupaIgor A Lavrov
Mar 23, 2021·Scientific Reports·Antonietta CannaSilvia Mangia
Apr 25, 2021·The Journal of Physiology·Pawan Sharma, Prithvi K Shah

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