Unique subgingival microbiota associated with periodontitis in cirrhosis patients

Scientific Reports
Anders JensenMogens Kilian

Abstract

Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most common oral diseases in cirrhosis patients. However, no studies have investigated the composition of the subgingival microbiome in patients suffering from periodontitis and liver cirrhosis. We analysed the subgingival microbiome in 21 patients with periodontitis and cirrhosis using long-reads Illumina sequencing. The subgingival microbiota was dominated by bacteria belonging to the Firmicutes phylum and to a lesser extend the Actinobacteria and Bacteroidetes phyla. Bacteria usually considered periodontal pathogens, like Porhyromonas ginigivalis, Tannerella forsythia, Treponema denticola, generally showed low abundancy. Comparing the microbiota in our patients with that of periodontitis patients and healthy controls of three other studies revealed that the periodontitis-associated subgingival microbiota in cirrhosis patients is composed of a unique microbiota of bacteria not normally associated with periodontitis. We ...Continue Reading

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Citations

Jan 29, 2019·Journal of Periodontology·Alexandru MesterRadu Septimiu Campian
Aug 18, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jasmohan S BajajSinem E Sahingur
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Jun 19, 2021·Oral Oncology·Avinash Kavarthapu, Kaarthikeyan Gurumoorthy

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Methods Mentioned

BETA
biopsy
PCR
Illumina sequencing

Software Mentioned

ThetaYC calculator
Mothur
Clearcut
R
vegan
Silva
PERMANOVA
LEfSe
PyroNoise

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