Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus

Virus Research
Sheila A HaleyWalter J Atwood

Abstract

Carcinoid syndrome is caused by the unregulated secretion of bioactive amines from neuroendocrine tumors arising primarily in the gastrointestinal tract and lungs. The incidence of carcinoid syndrome is 1-2/100,000 and the syndrome is thought to be increasing. Carcinoid tumors are relatively slow growing but can become highly metastatic. Currently, there is no effective therapy to inhibit cell proliferation or metastasis of neuroendocrine tumor (NET) disease. Polyomaviruses are a family of viruses that are able to transform cells and promote tumor formation. In this study, the polyomaviruses SV40, JCV, and BKV were used to assess the ability of polyomaviruses to productively infect a range of human carcinoid cell lines. Infection was assessed by the immunofluorescence detection of T antigen and V antigen. Viruses and cell lines that exhibited productive infections were subsequently assayed by FACS analysis for cell binding and dual promoter luciferase assay for early and late promoter activity. Most carcinoid cell lines were not susceptible to infection by polyomaviruses. However, BKV efficiently infected the pulmonary carcinoid H727 cell line but did not infect a control, non-carcinoid lung cell line (A549). BKV was found to b...Continue Reading

References

Oct 14, 2004·Journal of Virology·Sylvia EashWalter J Atwood
Nov 20, 2004·Science·Gwendolyn F ElphickWalter J Atwood
Aug 19, 2007·Journal of Virology·Aisling S DuganWalter J Atwood
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Dec 19, 2008·The Oncologist·Scott N PinchotHerbert Chen

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Citations

Feb 1, 2011·Expert Opinion on Therapeutic Targets·Mehtap Cakir, Ashley Grossman
Oct 8, 2013·PLoS Computational Biology·Sven-Eric SchelhornFrank Berthold
Jan 9, 2021·International Immunopharmacology·Parisa Shiri AghbashHossein Bannazadeh Baghi

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