PMID: 11912007Mar 26, 2002Paper

Unique therapeutic effects of the Japanese-Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice

Journal of Dermatological Science
Taisuke ItoF Furukawa

Abstract

Sairei-to, one of the Japanese-Chinese herbal medicines has been used for the treatment of various diseases, especially collagen disease and edema in nephrotic syndrome. However, the mechanism of the therapeutic effects remains uncertain. Therefore, we investigated the immunological changes of skin, kidney, spleen cells and serum in autoimmune-prone MRL/lpr, MRL/n and C57BL/6J mice treated with Sairei-to. In MRL/lpr mice treated with Sairei-to, the improvement of proteinuria, reduction in the number of hematoxylin bodies in kidney, and reduced serum levels of blood urea nitrogen were observed. These results indicate that Sairei-to can improve or inhibit the progression of lupus nephritis. The proportion of CD19 and the serum levels of IgG1, which is one of the pathogenesis of lupus dermatoses and lupus nephritis, were significantly reduced in Sairei-to-treated MRL/lpr mice. Therefore, it is suspected that the B cell function was suppressed by Sairei-to. In addition, CD4/8 ratio in spleen cells and the degree of lymphoproliferation in MRL/lpr mice also decreased. Interestingly, IL-4 producing spleen cells were increased significantly by ELISPOT assay, and IFN-gamma mRNA expressions were reduced in Sairei-to-treated MRL/lpr mice....Continue Reading

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Citations

Oct 16, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Toshikatsu KaburakiMasanori Niimi
Jul 23, 2013·Kidney International·Yifei ZhongJohn Cijiang He
Apr 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Kai-Peng HuangXiao Chen
Feb 14, 2016·Modern Rheumatology·Tatsuya ShimomatsuFukumi Furukawa
Apr 4, 2006·The Journal of Laboratory and Clinical Medicine·Ken WojcikowskiGlenda Gobe
Aug 9, 2020·F1000Research·Ichiro Kurokawa, Keisuke Nakase
Apr 16, 2019·Frontiers in Pharmacology·Liu TangHong Ding

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