Unit cell-based computer-aided manufacturing system for tissue engineering

Biofabrication
Hyun-Wook KangDong-Woo Cho

Abstract

Scaffolds play an important role in the regeneration of artificial tissues or organs. A scaffold is a porous structure with a micro-scale inner architecture in the range of several to several hundreds of micrometers. Therefore, computer-aided construction of scaffolds should provide sophisticated functionality for porous structure design and a tool path generation strategy that can achieve micro-scale architecture. In this study, a new unit cell-based computer-aided manufacturing (CAM) system was developed for the automated design and fabrication of a porous structure with micro-scale inner architecture that can be applied to composite tissue regeneration. The CAM system was developed by first defining a data structure for the computing process of a unit cell representing a single pore structure. Next, an algorithm and software were developed and applied to construct porous structures with a single or multiple pore design using solid freeform fabrication technology and a 3D tooth/spine computer-aided design model. We showed that this system is quite feasible for the design and fabrication of a scaffold for tissue engineering.

References

Jul 27, 2005·Journal of Biomechanics·George C EngelmayrMichael S Sacks
Oct 22, 2005·Annals of Biomedical Engineering·M A WettergreenM A K Liebschner
Sep 3, 2010·Biofabrication·William Lafayette MondyLes A Piegl

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Citations

May 8, 2014·BioMed Research International·Marco MravicAaron W James
Oct 16, 2015·Biotechnology Letters·Guifang Gao, Xiaofeng Cui
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Andrés Díaz LantadaJosefa Predestinación García-Ruíz
Nov 5, 2013·Acta Biomaterialia·S M GiannitelliA Rainer
May 31, 2013·Journal of Biomechanical Engineering·Jin Woo JungDong-Woo Cho
Apr 16, 2016·Annals of Biomedical Engineering·Jeong Hun ParkDong-Woo Cho
Nov 30, 2012·Biotechnology and Bioengineering·Young-Joon SeolDong-Woo Cho
Dec 17, 2016·Tissue Engineering and Regenerative Medicine·Jeong Hun ParkDong-Woo Cho
Mar 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Doo Yeon KwonMoon Suk Kim
May 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D M KirchmajerM In Het Panhuis
Oct 24, 2020·International Journal of Molecular Sciences·Jongmin KimDong-Woo Cho
Nov 20, 2020·Drug Discovery Today·Zaisam Al-DulimiAli Nokhodchi

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