United States liver allocation

Current Opinion in Organ Transplantation
Julie K Heimbach

Abstract

The current review discusses the system of liver allocation in the United States, the adoption of the national liver review board (NLRB), and the pending major change to the system of distribution (acuity circle model). The system of liver allocation in the United States is based on the model for end-stage liver disease (MELD) score, a formula which uses commonly available tests (international normalized ratio, bilirubin, creatinine, and recently, sodium) prioritizes candidates on the waitlist according to likelihood of death without access to transplant. This review provides an overview of modifications to MELD allocation and well as a summary of the benefits and weaknesses. The review also details the pending major revision to the distribution of liver allografts, which attempts to reduce the geographic disparity in access by sharing across a broader geographic area. Finally, the review describes the implementation of the NLRB, which replaced the previous system in May 2019. The system of liver allocation and distribution in the United States has been subject to ongoing optimization, though the recent adoption of the NLRB, and pending change to distribution will significantly impact the system with the goal of reducing geogra...Continue Reading

References

Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerW R Kim
Oct 28, 2004·Gastroenterology·Russell H WiesnerDavid C Mulligan
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B FreemanA M Harper
May 16, 2006·Gastroenterology·Scott W BigginsGoran Klintmalm
Jun 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P SharmaV Balan
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick S KamathUNKNOWN Advanced Liver Disease Study Group
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F Y YaoJ P Roberts
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K WashburnR Freeman
Sep 17, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A B MassieD L Segev
Jul 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick Grant NorthupCurtis Kent Argo
Jun 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Allison J KwongW Ray Kim
Jul 12, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K RossR J Lynch
Jan 10, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Xun LuoDorry L Segev
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach
Oct 13, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tanveen IshaqueDorry L Segev

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Citations

Feb 23, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nabeel A WahidRobert S Brown

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