Universal cell type identifier based on number theory

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Antonio Cosma

Abstract

Cell type classification and handling is a key issue for understanding biological systems. The advent of high multiplexing technologies increased the complexity of the classification process and new tools are needed to support the organization of this knowledge. I propose a classification based on both prime numbers and the fundamental theorem of arithmetic. As a not limiting example, I show the application of this method to unambiguously define any existing cell type using the CD nomenclature established by the Human Leukocyte Differentiation Antigens Workshops. This system allows for the unique identification of any possible combination of markers hence any cell population without previous knowledge and without the need to increment the system. This method can be the future basis of any database and ontology system dealing with cell types and beyond the biological field applies to the description of any entity characterized by a list of discrete qualities. © 2018 International Society for Advancement of Cytometry.

References

Feb 8, 2005·Genome Biology·Jonathan BardMichael Ashburner
Dec 7, 2014·Bioinformatics·Mélanie CourtotRyan R Brinkman
Jul 23, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Antonio Cosma
Nov 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo EngelGeorgina Clark
Oct 27, 2017·Nature·Orit Rozenblatt-RosenSarah A Teichmann

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Citations

Oct 9, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Tomas Kalina

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