Universal response quantification approach using a Corona Charged Aerosol Detector (CAD) - Application on linear and cyclic oligomers extractable from polycondensate plastics polyesters, polyamides and polyarylsulfones

Journal of Chromatography. a
Martin EckardtT J Simat

Abstract

In terms of risk assessment especially for known and unknown substances migrating from food contact materials, quantification without corresponding reference substances currently poses a challenge. In the present study, the opportunity of a universal response quantification approach was evaluated by using a corona charged aerosol detector (CAD) for liquid chromatography combined with inverse gradient compensation. Characteristics of CAD detection in dependence of substance properties were analyzed with 46 randomly chosen reference substances. An almost equal CAD response (±20%) was achieved for non-volatile substances with a molecular weight of minimum 400 g/mol and a vapor pressure of maximum 10-8 Torr. We empirically defined an analytical parameter, Q50/35, the quotient of CAD peak areas at CAD evaporator temperatures of 50 °C and 35 °C, to predict the adequacy of the CAD universal response approach for quantification of known and unknown analyte substances. Exemplarily, we applied the CAD universal quantification approach for the determination of extractable oligomers below 1000 g/mol from a variety of food contact polycondensate plastic materials (e.g. polyesters like polyethylene terephthalate, polybutylene terephthalate, ...Continue Reading

Citations

May 30, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Martin EckardtThomas J Simat
Sep 4, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Martin EckardtThomas J Simat
Aug 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rafael Paseiro-CerratoTimothy H Begley
Jul 25, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Martin EckardtThomas J Simat
Sep 17, 2020·Journal of Separation Science·Wouter C KnolRon A H Peters
Feb 3, 2020·Journal of Chromatography. a·Klaus Schilling, Ulrike Holzgrabe
Nov 16, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Marie KubicovaThomas J Simat
Jan 27, 2022·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Cristina NerínPeter Oldring

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