Universal structures of normal and pathological heart rate variability

Scientific Reports
Alfonso M Gañán-Calvo, Juan Fajardo-López

Abstract

The circulatory system of living organisms is an autonomous mechanical system softly tuned with the respiratory system, and both developed by evolution as a response to the complex oxygen demand patterns associated with motion. Circulatory health is rooted in adaptability, which entails an inherent variability. Here, we show that a generalized N-dimensional normalized graph representing heart rate variability reveals two universal arrhythmic patterns as specific signatures of health one reflects cardiac adaptability, and the other the cardiac-respiratory rate tuning. In addition, we identify at least three universal arrhythmic profiles whose presences raise in proportional detriment of the two healthy ones in pathological conditions (myocardial infarction; heart failure; and recovery from sudden death). The presence of the identified universal arrhythmic structures together with the position of the centre of mass of the heart rate variability graph provide a unique quantitative assessment of the health-pathology gradient.

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Citations

Jul 4, 2018·Scientific Reports·Alfonso M Gañán-CalvoMarek Malik
Jun 3, 2021·International Journal of Environmental Research and Public Health·Hsiu-Chin HsuMei-Hsiang Lin

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Methods Mentioned

BETA
NMR

Software Mentioned

echoCG

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